| Dokumenttyp | Erscheinungsjahr | Titel | Autoren | Herausgeber |
|---|
| article | 2024 | Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS) | Floroiu, Andreea; Loretz, Brigitta; Krämer, Johannes; Lehr, Claus-Michael | |
| article | 2024 | Targeting Intracellular Bacteria with Dual Drug-loaded Lactoferrin Nanoparticles | Andima, Moses; Boese, Annette; Paul, Pascal; Koch, Marcus; Loretz, Brigitta; Lehr, Claus-Michael | |
| article | 2024 | A New Class of Polyion Complex Vesicles (PIC-somes) to Improve Antimicrobial Activity of Tobramycin in Pseudomonas Aeruginosa Biofilms | Yildirim, Turgay; Bali, Aghiad; Koch, Marcus; Paul, Pascal; Latta, Lorenz; Schneider-Daum, Nicole; Gallei, Markus; Lehr, Claus-Michael | |
| article | 2023 | Simulated Tempering-Enhanced Umbrella Sampling Improves Convergence of Free Energy Calculations of Drug Membrane Permeation | Sousa, Carla F.; Becker, Robert A.; Lehr, Claus-Michael; Kalinina, Olga V.; Hub, Jochen S. | |
| article | 2023 | A Monoclonal Human Alveolar Epithelial Cell Line ("Arlo") with Pronounced Barrier Function for Studying Drug Permeability and Viral Infections | Carius, Patrick; Jungmann, Annemarie; Bechtel, Marco; Grißmer, Alexander; Boese, Annette; Gasparoni, Gilles; Salhab, Abdulrahman; Seipelt, Ralf; Urbschat, Klaus; Richter, Clémentine; Meier, Carola; Bojkova, Denisa; Cinatl, Jindrich; Walter, Jörn Erik; Schneider-Daum, Nicole; Lehr, Claus-Michael | |
| article | 2023 | Disrupting Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor | Berwanger, Aylin; Stein, Saskia C.; Kany, Andreas M.; Gartner, Melissa; Loretz, Brigitta; Lehr, Claus-Michael; Hirsch, Anna; Schulz, Thomas F.; Empting, Martin | |
| article | 2023 | Establishment of an In Bacterio Assay for the Assessment of Carbon Storage Regulator A (CsrA) Inhibitors | Yingwen, Wu; Zoller, Ben G. E.; Kamal, Mohamed Ashraf Mostafa; Hotop, Sven-Kevin; Lehr, Claus-Michael; Brönstrup, Mark; Dersch, Petra; Empting, Martin | |
| article | 2023 | Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections | Konstantinović, Jelena; Kany, Andreas M.; Alhayek, Alaa; Abdelsamie, Ahmed S.; Sikandar, Asfandyar; Voos, Katrin; Yiwen, Yao; Andreas, Anastasia; Shafiei, Roya; Loretz, Brigitta; Schönauer, Esther; Bals, Robert; Brandstetter, Hans; Hartmann, Rolf W.; Ducho, Christian; Lehr, Claus-Michael; Beißwenger, Christoph; Müller, Rolf; Rox, Katharina; Haupenthal, Jörg; Hirsch, Anna | |
| article | 2023 | Cell-Derived Vesicles for Antibiotic Delivery-Understanding the Challenges of a Biogenic Carrier System | Heinrich, Eilien; Hartwig, Olga; Walt, Christine; Kardani, Arefeh; Koch, Marcus; Jahromi, Leila Pourtalebi; Hoppstädter, Jessica; Kiemer, Alexandra K.; Loretz, Brigitta; Lehr, Claus-Michael; Fuhrmann, Gregor | |
| article | 2023 | Proteoid biodynamers for safe mRNA transfection via pH-responsive nanorods enabling endosomal escape | Lee, Sangeun; Nasr, Sarah Samir Mahmoud; Rasheed, Sari Shawki; Liu, Yun; Hartwig, Olga; Kaya, Cansu; Boese, Annette; Koch, Marcus; Herrmann, Jennifer; Müller, Rolf; Loretz, Brigitta; Buhler, Eric; Hirsch, Anna; Lehr, Claus-Michael | |
| article | 2023 | 3D bioprinting ofE. coliMG1655 biofilms on human lung epithelial cells for building complexin vitroinfection models | Aliyazdi, Samy; Frisch, Sarah; Hidalgo, Alberto; Frank, Nicolas Alexander; Krug, Daniel; Müller, Rolf; Schaefer, Ulrich F.; Vogt, Thomas; Loretz, Brigitta; Lehr, Claus-Michael | |
| article | 2023 | Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development | Bali, Aghiad; Kamal, Mohamed A. M.; Loretz, Brigitta; Lehr, Claus-Michael | |
| article | 2023 | pH-Responsive Dynaplexes as Potent Apoptosis Inductors by Intracellular Delivery of Survivin siRNA | Liu, Yun; Ashmawy, Salma; Latta, Lorenz; Weiss, Agnes-Valencia; Kiefer, Alexander F.; Nasr, Sarah; Loretz, Brigitta; Hirsch, Anna K. H.; Lee, Sangeun; Lehr, Claus-Michael | |
| article | 2022 | Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase | Mehanny, Mina; Kroniger, Tobias; Koch, Marcus; Hoppstädter, Jessica; Becher, Dörte; Kiemer, Alexandra K.; Lehr, Claus-Michael; Fuhrmann, Gregor | |
| article | 2022 | Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes | Metelkina, Olga; Huck, Benedikt; O'Connor, Jonathan S.; Koch, Marcus; Manz, Andreas; Lehr, Claus-Michael; Titz, Alexander | |
| article | 2022 | Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery | Huck, Benedikt C.; Thiyagarajan, Durairaj; Bali, Aghiad; Boese, Annette; Besecke, Karen F. W.; Hozsa, Constantin; Gieseler, Robert K.; Furch, Marcus; Carvalho-Wodarz, Cristiane; Waldow, Franziska; Schwudke, Dominik; Metelkina, Olga; Titz, Alexander; Huwer, Hanno; Schwarzkopf, Konrad; Hoppstädter, Jessica; Kiemer, Alexandra Kathrin; Koch, Marcus; Loretz, Brigitta; Lehr, Claus-Michael | |
| article | 2022 | Spray-dried pneumococcal membrane vesicles are promising candidates for pulmonary immunization | Mehanny Habeeb Kaldas, Mina; Boese, Annette; Bornamehr, Behnoosh; Hoppstädter, Jessica; Presser, Volker; Kiemer, Alexandra K.; Lehr, Claus-Michael; Fuhrmann, Gregor | |
| article | 2022 | Lipid-Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells : Impact of Lipid Composition on Performance in Different Media | Kliesch, Lena; Delandre, Simon; Gabelmann, Aljoscha; Koch, Marcus; Schulze, Kai; Guzmán, Carlos A.; Loretz, Brigitta; Lehr, Claus-Michael | |
| article | 2021 | Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals | Thiyagarajan, Durairaj; Huck, Benedikt; Nothdurft, Birgit; Koch, Marcus; Rudolph, David; Rutschmann, Mark; Feldmann, Claus; Hozsa, Constantin; Furch, Marcus; Besecke, Karen F. W.; Gieseler, Robert K.; Loretz, Brigitta; Lehr, Claus-Michael | |
| article | 2021 | Human Skin Permeation Enhancement Using PLGA Nanoparticles Is Mediated by Local pH Changes | Luengo, Javiana; Schneider, Marc; Schneider, Anna M.; Lehr, Claus-Michael; Schaefer, Ulrich F. | |
| article | 2021 | A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms | Schütz, Christian; Ho, Duy-Khiet; Hamed, Mostafa Mohamed; Abdelsamie, Ahmed Saad; Röhrig, Teresa; Herr, Christian; Kany, Andreas Martin; Rox, Katharina; Schmelz, Stefan; Siebenbürger, Lorenz; Wirth, Marius; Börger, Carsten; Yahiaoui, Samir; Bals, Robert; Scrima, Andrea; Blankenfeldt, Wulf; Horstmann, Justus Constantin; Christmann, Rebekka; Murgia, Xabier; Koch, Marcus; Berwanger, Aylin; Loretz, Brigitta; Hirsch, Anna Katharina Herta; Hartmann, Rolf Wolfgang; Lehr, Claus-Michael; Empting, Martin | |
| article | 2021 | An Outer Membrane Vesicle-Based Permeation Assay (OMPA) for Assessing Bacterial Bioavailability | Richter, Robert; Kamal, Mohamed A. M.; Koch, Marcus; Niebuur, Bart-Jan; Huber, Anna-Lena; Goes Conceicao, Adriely; Volz, Carsten; Vergalli, Julia; Kraus, Tobias; Müller, Rolf; Schneider-Daum, Nicole; Fuhrmann, Gregor; Pagès, Jean-Marie; Lehr, Claus-Michael | |
| article | 2021 | Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems | Nasr, Sarah S.; Lee, Sangeun; Thiyagarajan, Durairaj; Boese, Annette; Loretz, Brigitta; Lehr, Claus-Michael | |
| article | 2021 | Transferring Microclusters of P. aeruginosa Biofilms to the Air : Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin | Horstmann, Justus C.; Laric, Annabelle; Boese, Annette; Yildiz, Daniela; Röhrig, Teresa; Empting, Martin; Frank, Nicolas; Krug, Daniel; Müller, Rolf; Schneider-Daum, Nicole; de Souza Carvalho-Wodarz, Cristiane; Lehr, Claus-Michael | |
| Other | 2021 | Editorial: Innovative In Vitro Models for Pulmonary Physiology and Drug Delivery in Health and Disease | Lehr, Claus-Michael; Yeo, Leslie; Sznitman, Josué | |
| article | 2021 | Mastering the Gram-negative bacterial barrier : Chemical approaches to increase bacterial bioavailability of antibiotics | Ropponen, Henni-Karoliina; Richter, Robert; Hirsch, Anna K. H.; Lehr, Claus-Michael | |
| article | 2021 | Towards the sustainable discovery and development of new antibiotics | Miethke, Marcus; Pieroni, Marco; Weber, Tilmann; Brönstrup, Mark; Hammann, Peter; Halby, Ludovic; Arimondo, Paola B.; Glaser, Philippe; Aigle, Bertrand; Bode, Helge B.; Moreira, Rui; Li, Yanyan; Luzhetskyy, Andriy; Medema, Marnix H.; Pernodet, Jean-Luc; Stadler, Marc; Tormo, José Rubén; Genilloud, Olga; Truman, Andrew W.; Weissman, Kira J.; Takano, Eriko; Sabatini, Stefano; Stegmann, Evi; Brötz-Oesterhelt, Heike; Wohlleben, Wolfgang; Seemann, Myriam; Empting, Martin; Hirsch, Anna K. H.; Loretz, Brigitta; Lehr, Claus-Michael; Titz, Alexander; Herrmann, Jennifer; Jaeger, Timo; Alt, Silke; Hesterkamp, Thomas; Winterhalter, Mathias; Schiefer, Andrea; Pfarr, Kenneth; Hoerauf, Achim; Graz, Heather; Graz, Michael; Lindvall, Mika; Ramurthy, Savithri; Karlén, Anders; van Dongen, Maarten; Petkovic, Hrvoje; Keller, Andreas; Peyrane, Frédéric; Donadio, Stefano; Fraisse, Laurent; Piddock, Laura J. V.; Gilbert, Ian H.; Moser, Heinz E.; Müller, Rolf | |
| article | 2020 | Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases | Christmann, Rebekka; Ho, Duy-Khiet; Wilzopolski, Jenny; Lee, Sangeun; Koch, Marcus; Loretz, Brigitta; Vogt, Thomas; Bäumer, Wolfgang; Schaefer, Ulrich F.; Lehr, Claus-Michael | |
| article | 2020 | Itaconic Acid Increases the Efficacy of Tobramycin against Pseudomonas aeruginosa Biofilms | Ho, Duy-Khiet; De Rossi, Chiara; Loretz, Brigitta; Murgia, Xabier; Lehr, Claus-Michael | |
| article | 2020 | Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility | Montefusco-Pereira, Carlos V.; Formicola, Beatrice; Goes, Adriely; Re, Francesca; Marrano, Claudia A.; Mantegazza, Francesco; Carvalho-Wodarz, Cristiane; Fuhrmann, Gregor; Caneva, Enrico; Nicotra, Francesco; Lehr, Claus-Michael; Russo, Laura | |
| article | 2020 | Streptococcal Extracellular Membrane Vesicles Are Rapidly Internalized by Immune Cells and Alter Their Cytokine Release | Mehanny, Mina; Koch, Marcus; Lehr, Claus-Michael; Fuhrmann, Gregor | |
| article | 2020 | Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform | Ho, Duy-Khiet; Christmann, Rebekka; Murgia, Xabier; De Rossi, Chiara; Frisch, Sarah; Koch, Marcus; Schaefer, Ulrich F.; Loretz, Brigitta; Desmaele, Didier; Couvreur, Patrick; Lehr, Claus-Michael | |
| article | 2020 | pH-Dependent morphology and optical properties of lysine-derived molecular biodynamers | Lee, Sangeun; Kaya, Cansu; Jang, Hongje; Koch, Marcus; Loretz, Brigitta; Buhler, Eric; Lehr, Claus-Michael; Hirsch, Anna Katharina Herta | |
| article | 2020 | Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections | Ho, Duy-Khiet; Murgia, Xabier; De Rossi, Chiara; Christmann, Rebekka; Hüfner de Mello Martins, Antonio G.; Koch, Marcus; Andreas, Anastasia; Herrmann, Jennifer; Müller, Rolf; Empting, Martin; Hartmann, Rolf W.; Desmaele, Didier; Loretz, Brigitta; Couvreur, Patrick; Lehr, Claus-Michael | |
| article | 2020 | Nanoparticle Targeting to Scalp Hair Follicles: New Perspectives for a Topical Therapy for Alopecia Areata | Christmann, Rebekka; Thomas, Carla; Jager, Nadine; Raber, Anne S.; Loretz, Brigitta; Schaefer, Ulrich F.; Tschernig, Thomas; Vogt, Thomas; Lehr, Claus-Michael | |
| article | 2020 | A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria | Richter, Robert; Kamal, Mohamed A. M.; García-Rivera, Mariel A.; Kaspar, Jerome; Junk, Maximilian; Elgaher, Walid A. M.; Srikakulam, Sanjay Kumar; Gress, Alexander; Beckmann, Anja; Grißmer, Alexander; Meier, Carola; Vielhaber, Michael; Kalinina, Olga; Hirsch, Anna K.H.; Hartmann, Rolf W.; Brönstrup, Mark; Schneider-Daum, Nicole; Lehr, Claus-Michael | |
| article | 2020 | Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection | Murgia, Xabier; Kany, Andreas M.; Herr, Christian; Ho, Duy-Khiet; De Rossi, Chiara; Bals, Robert; Lehr, Claus-Michael; Hirsch, Anna K. H.; Hartmann, Rolf W.; Empting, Martin; Röhrig, Teresa | |
| article | 2020 | Towards a Continuous Manufacturing Process of Protein-Loaded Polymeric Nanoparticle Powders | Schiller, Stefan; Hanefeld, Andrea; Schneider, Marc; Lehr, Claus-Michael | |
| article | 2020 | P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives | Montefusco-Pereira, Carlos Victor; Horstmann, Justus C.; Ebensen, Thomas; Beisswenger, Christoph; Bals, Robert; Guzmán, Carlos A.; Schneider-Daum, Nicole; Carvalho-Wodarz, Cristiane de Souza; Lehr, Claus-Michael | |
| article | 2019 | Macro- and Microrheological Properties of Mucus Surrogates in Comparison to Native Intestinal and Pulmonary Mucus | Huck, Benedikt C.; Hartwig, Olga; Biehl, Alexander; Schwarzkopf, Konrad; Wagner, Christian; Loretz, Brigitta; Murgia, Xabier; Lehr, Claus-Michael | |
| article | 2019 | Author Correction: Extracellular vesicles protect glucuronidase model enzymes during freeze-drying | Frank, Julia; Richter, Maximilian; de Rossi, Chiara; Lehr, Claus-Michael; Fuhrmann, Kathrin; Fuhrmann, Gregor | |
| article | 2019 | Preparation, characterisation and in vitro antibacterial property of ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection | Nnamani, Petra; Ugwu, Agatha; Ibezim, Emmanuel; Onoja, Simon; Odo, Amelia; Windbergs, Maike; Rossi, Chiara; Lehr, Claus-Michael; Attama, Anthony | |
| article | 2019 | Preferential uptake of chitosan-coated PLGA nanoparticles by primary human antigen presenting cells | Durán, Verónica; Yasar, Hanzey; Becker, Jennifer; Thiyagarajan, Durairaj; Loretz, Brigitta; Kalinke, Ulrich; Lehr, Claus-Michael | |
| article | 2018 | Farnesylated Glycol Chitosan as a Platform for Drug Delivery: Synthesis, Characterization, and Investigation of Mucus-Particle Interactions | Ho, Duy-Khiet; Frisch, Sarah; Biehl, Alexander; Terriac, Emmanuel; De Rossi, Chiara; Schwarzkopf, Konrad; Lautenschläger, Franziska; Loretz, Brigitta; Murgia, Xabier; Lehr, Claus-Michael | |
| article | 2018 | Extracellular vesicles protect glucuronidase model enzymes during freeze-drying | Frank, Julia; Richter, Maximilian; de Rossi, Chiara; Lehr, Claus-Michael; Fuhrmann, Kathrin; Fuhrmann, Gregor | |
| article | 2018 | Can lifecycle management safeguard innovation in the pharmaceutical industry? | Hering, Stefanie; Loretz, Brigitta; Friedli, Thomas; Lehr, Claus-Michael; Stieneker, Frank | |
| article | 2018 | Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery | Yasar, Hanzey; Ho, Duy-Khiet; De Rossi, Chiara; Herrmann, Jennifer; Gordon, Sarah; Loretz, Brigitta; Lehr, Claus-Michael | |
| article | 2018 | Murine Alveolar Epithelial Cells and Their Lentivirus-mediated Immortalisation | Sapich, Sandra; Hittinger, Marius; Hendrix-Jastrzebski, Remi; Repnik, Urska; Griffiths, Gareth; May, Tobias; Wirth, Dagmar; Bals, Robert; Schneider-Daum, Nicole; Lehr, Claus-Michael | |
| article | 2017 | A Model for the Transient Subdiffusive Behavior of Particles in Mucus | Ernst, Matthias; John, Thomas; Guenther, Marco; Wagner, Christian; Schaefer, Ulrich F.; Lehr, Claus-Michael | |
| article | 2017 | A foam model highlights the differences of the macro- and microrheology of respiratory horse mucus | Gross, Andreas; Torge, Afra; Schaefer, Ulrich F.; Schneider, Marc; Lehr, Claus-Michael; Wagner, Christian | |
| article | 2017 | Barriers and motivations for non-invasive drug delivery | Loretz, Brigitta; Schneider-Daum, Nicole; Windbergs, Maike; Schaefer, Ulrich F.; Schneider, Marc; Lehr, Claus-Michael | |
