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doi:10.22028/D291-31487
Titel: | Preparation, characterisation and in vitro antibacterial property of ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection |
VerfasserIn: | Nnamani, Petra Ugwu, Agatha Ibezim, Emmanuel Onoja, Simon Odo, Amelia Windbergs, Maike Rossi, Chiara Lehr, Claus-Michael Attama, Anthony |
Sprache: | Englisch |
Titel: | Journal of microencapsulation : microcapsules, liposomes, nanocapsules, microcells |
Bandnummer: | 36 |
Heft: | 1 |
Startseite: | 32 |
Endseite: | 42 |
Verlag/Plattform: | Taylor & Francis |
Erscheinungsjahr: | 2019 |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Context: In this study, controlled ciprofloxacin (CIPRO) nanostrustructured lipid carriers of Precirol® ATO 5/Transcutol® HP (batch A) and tallow fat/Transcutol® HP (batch B) was carreid out. Objective: The aim was to improve solubility and bioavailability of CIPRO. Objective: Study of controlled ciprofloxacin (CIPRO) nanostructured lipid carriers of Precirol® ATO 5/Transcutol® HP (batch A) and tallow fat/Transcutol® HP (batch B). Methods: CIPRO concentrations C1-5 (0.0, 0.2, 0.5, 0.8, and 1.0% w/w) as AC1-5 and BC1-5 were prepared by hot homogenisation and characterised by zetasizer, differential scanning calorimetry, Fourier transform infra-red spectroscopy, in vitro drug release and growth inhibitory zone diameter (IZD) on agar-seeded Bacillus subtilis. Results: AC5 achieved polydispersed particles of ∼605 nm, 92% encapsulation efficiency (EE) and -28 mV similar to BC5 (∼789 nm, 91% EE, and -31 mV). Crystallinity indices (AC5 and BC5) were low at 3 and 5%, respectively. CIPRO release in AC5 was ∼98% in SGF (pH 1.2) and BC5 similarly ∼98% in SIF (pH 6.8). Conclusions: AC5 had superior growth inhibition of B. subtilis at lower concentration (1.2 µg/mL) than BC5 and CIPRO controls; hence could serve as possible sustained delivery system of CIPRO. |
DOI der Erstveröffentlichung: | 10.1080/02652048.2019.1582724 |
URL der Erstveröffentlichung: | https://www.tandfonline.com/doi/full/10.1080/02652048.2019.1582724 |
Link zu diesem Datensatz: | hdl:20.500.11880/29425 http://dx.doi.org/10.22028/D291-31487 |
ISSN: | 0265-2048 1464-5246 |
Datum des Eintrags: | 14-Jul-2020 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Pharmazie |
Professur: | NT - Prof. Dr. Claus-Michael Lehr |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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