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Titel: Preparation, characterisation and in vitro antibacterial property of ciprofloxacin-loaded nanostructured lipid carrier for treatment of Bacillus subtilis infection
VerfasserIn: Nnamani, Petra
Ugwu, Agatha
Ibezim, Emmanuel
Onoja, Simon
Odo, Amelia
Windbergs, Maike
Rossi, Chiara
Lehr, Claus-Michael
Attama, Anthony
Sprache: Englisch
Titel: Journal of microencapsulation : microcapsules, liposomes, nanocapsules, microcells
Bandnummer: 36
Heft: 1
Startseite: 32
Endseite: 42
Verlag/Plattform: Taylor & Francis
Erscheinungsjahr: 2019
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Context: In this study, controlled ciprofloxacin (CIPRO) nanostrustructured lipid carriers of Precirol® ATO 5/Transcutol® HP (batch A) and tallow fat/Transcutol® HP (batch B) was carreid out. Objective: The aim was to improve solubility and bioavailability of CIPRO. Objective: Study of controlled ciprofloxacin (CIPRO) nanostructured lipid carriers of Precirol® ATO 5/Transcutol® HP (batch A) and tallow fat/Transcutol® HP (batch B). Methods: CIPRO concentrations C1-5 (0.0, 0.2, 0.5, 0.8, and 1.0% w/w) as AC1-5 and BC1-5 were prepared by hot homogenisation and characterised by zetasizer, differential scanning calorimetry, Fourier transform infra-red spectroscopy, in vitro drug release and growth inhibitory zone diameter (IZD) on agar-seeded Bacillus subtilis. Results: AC5 achieved polydispersed particles of ∼605 nm, 92% encapsulation efficiency (EE) and -28 mV similar to BC5 (∼789 nm, 91% EE, and -31 mV). Crystallinity indices (AC5 and BC5) were low at 3 and 5%, respectively. CIPRO release in AC5 was ∼98% in SGF (pH 1.2) and BC5 similarly ∼98% in SIF (pH 6.8). Conclusions: AC5 had superior growth inhibition of B. subtilis at lower concentration (1.2 µg/mL) than BC5 and CIPRO controls; hence could serve as possible sustained delivery system of CIPRO.
DOI der Erstveröffentlichung: 10.1080/02652048.2019.1582724
URL der Erstveröffentlichung: https://www.tandfonline.com/doi/full/10.1080/02652048.2019.1582724
Link zu diesem Datensatz: hdl:20.500.11880/29425
http://dx.doi.org/10.22028/D291-31487
ISSN: 0265-2048
1464-5246
Datum des Eintrags: 14-Jul-2020
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Claus-Michael Lehr
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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