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doi:10.22028/D291-42572
Titel: | Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development |
VerfasserIn: | Bali, Aghiad Kamal, Mohamed A. M. Loretz, Brigitta Lehr, Claus-Michael |
Sprache: | Englisch |
Titel: | Advanced functional materials |
Bandnummer: | 33 |
Heft: | 45 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2023 |
DDC-Sachgruppe: | 500 Naturwissenschaften |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | With the emerging problem of antimicrobial resistance, the world is facing a slow but dangerous pandemic. While the discovery of novel antibiotics is reaching a nearly exhaustive end, new concepts for anti-infective drugs are emerging. So-called pathoblockers aim to de-weaponize bacteria rather than just killing them. As the target of these molecules is typically located intracellularly, however, hitherto almost unnoticed biological barriers are emerging such as the biofilm matrix, the bacterial cell envelope, efflux pumps, and eventual bacterial metabolism. This leads to a new paradigm that is to maximize bacterial bioavailability. To overcome the bacterial barriers, especially when further optimization of the active molecules is not possible, functional materials are needed to engineer innovative delivery systems. Those may not only enable novel anti-infective molecules to reach their targets, but will also improve the bacterial bioavailability of existing anti-infectives. Additionally, there is a need for better infection models that allow studying drug effects on both the bacteria and the host in a relevant manner as needed for rational anti-infective drug development. |
DOI der Erstveröffentlichung: | 10.1002/adfm.202304370 |
URL der Erstveröffentlichung: | https://onlinelibrary.wiley.com/doi/10.1002/adfm.202304370 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-425727 hdl:20.500.11880/38195 http://dx.doi.org/10.22028/D291-42572 |
ISSN: | 1616-3028 1616-301X |
Datum des Eintrags: | 7-Aug-2024 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Pharmazie |
Professur: | NT - Prof. Dr. Claus-Michael Lehr |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Adv Funct Materials - 2023 - Bali - Functional Materials to Overcome Bacterial Barriers and Models to Advance Their.pdf | 3,78 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons