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Titel: Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development
VerfasserIn: Bali, Aghiad
Kamal, Mohamed A. M.
Loretz, Brigitta
Lehr, Claus-Michael
Sprache: Englisch
Titel: Advanced functional materials
Bandnummer: 33
Heft: 45
Verlag/Plattform: Wiley
Erscheinungsjahr: 2023
DDC-Sachgruppe: 500 Naturwissenschaften
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: With the emerging problem of antimicrobial resistance, the world is facing a slow but dangerous pandemic. While the discovery of novel antibiotics is reaching a nearly exhaustive end, new concepts for anti-infective drugs are emerging. So-called pathoblockers aim to de-weaponize bacteria rather than just killing them. As the target of these molecules is typically located intracellularly, however, hitherto almost unnoticed biological barriers are emerging such as the biofilm matrix, the bacterial cell envelope, efflux pumps, and eventual bacterial metabolism. This leads to a new paradigm that is to maximize bacterial bioavailability. To overcome the bacterial barriers, especially when further optimization of the active molecules is not possible, functional materials are needed to engineer innovative delivery systems. Those may not only enable novel anti-infective molecules to reach their targets, but will also improve the bacterial bioavailability of existing anti-infectives. Additionally, there is a need for better infection models that allow studying drug effects on both the bacteria and the host in a relevant manner as needed for rational anti-infective drug development.
DOI der Erstveröffentlichung: 10.1002/adfm.202304370
URL der Erstveröffentlichung: https://onlinelibrary.wiley.com/doi/10.1002/adfm.202304370
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-425727
hdl:20.500.11880/38195
http://dx.doi.org/10.22028/D291-42572
ISSN: 1616-3028
1616-301X
Datum des Eintrags: 7-Aug-2024
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Claus-Michael Lehr
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons