| Dokumenttyp | Erscheinungsjahr | Titel | Autoren | Herausgeber |
|---|
| article | 2024 | Big Epidemiology: The Birth, Life, Death, and Resurgence of Diseases on a Global Timescale | Bragazzi, Nicola Luigi; Lehr, Thorsten | |
| article | 2024 | Client satisfaction, safety, and insights from a three-season survey on influenza vaccinations delivered at community pharmacies in Germany | Werthner, Quirin; Faehrmann, Laura; Och, Katharina; Bragazzi, Nicola Luigi; Hug, Martin Johannes; Stahmeyer, Jona; Burger, Birte; Bauer, Cosima; Selzer, Dominik; Schwalbe, Oliver; May, Uwe; Lehr, Thorsten | |
| article | 2024 | Does a carboxamide moiety alter the toxicokinetics of synthetic cannabinoids? A study after pulmonary and intravenous administration of cumyl-5F-P7AICA to pigs | Walle, Nadja; Dings, Christiane; Zaher, Omar; Doerr, Adrian A.; Peters, Benjamin; Laschke, Matthias W.; Lehr, Thorsten; Menger, Michael D.; Schmidt, Peter H.; Meyer, Markus R.; Schaefer, Nadine | |
| article | 2024 | Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically-Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy | Marok, Fatima Zahra; Wojtyniak, Jan-Georg; Selzer, Dominik; Dallmann, Robert; Swen, Jesse J.; Guchelaar, Henk-Jan; Schwab, Matthias; Lehr, Thorsten | |
| article | 2024 | Population kinetic/pharmacodynamic modelling of the haemodynamic effects of cafedrine/theodrenaline (Akrinor) under general anaesthesia | Dings, Christiane; Lehr, Thorsten; Vojnar, Benjamin; Gaik, Christine; Koch, Tilo; Eberhart, Leopold H. J.; Huljic-Lankinen, Susanne; Murst, Melanie; Kreuer, Sascha | |
| article | 2024 | Physiologically based pharmacokinetic modeling of imatinib and N-desmethyl imatinib for drug-drug interaction predictions | Loer, Helena Leonie Hanae; Kovar, Christina; Rüdesheim, Simeon; Marok, Fatima Zahra; Fuhr, Laura Maria; Selzer, Dominik; Schwab, Matthias; Lehr, Thorsten | |
| article | 2024 | A physiologically-based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions | Kovar, Christina; Loer, Helena Leonie Hanae; Rüdesheim, Simeon; Fuhr, Laura Maria; Marok, Fatima Zahra; Selzer, Dominik; Schwab, Matthias; Lehr, Thorsten | |
| article | 2024 | Effect of vaccinations and school restrictions on the spread of COVID-19 in different age groups in Germany | Dings, Christiane; Selzer, Dominik; Bragazzi, Nicola Luigi; Möhler, Eva; Wenning, Markus; Gehrke, Thomas; Richter, Ulf; Nonnenmacher, Alexandra; Brinkmann, Folke; Rothoeft, Tobias; Zemlin, Michael; Lücke, Thomas; Lehr, Thorsten | |
| article | 2023 | A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug–Drug Interaction Perpetrators | Marok, Fatima Zahra; Wojtyniak, Jan-Georg; Fuhr, Laura Maria; Selzer, Dominik; Schwab, Matthias; Weiss, Johanna; Haefeli, Walter Emil; Lehr, Thorsten | |
| article | 2023 | Significant impact of time-of-day variation on metformin pharmacokinetics | Türk, Denise; Scherer, Nina; Selzer, Dominik; Dings, Christiane; Hanke, Nina; Dallmann, Robert; Schwab, Matthias; Timmins, Peter; Nock, Valerie; Lehr, Thorsten | |
| article | 2023 | Physiologically based pharmacokinetic modeling of tacrolimus for food-drug and CYP3A drug-drug-gene interaction predictions | Loer, Helena Leonie Hanae; Feick, Denise; Rüdesheim, Simeon; Selzer, Dominik; Schwab, Matthias; Teutonico, Donato; Frechen, Sebastian; van der Lee, Maaike; Moes, Dirk Jan A. R.; Swen, Jesse J.; Lehr, Thorsten | |
| article | 2023 | Physiologically Based Pharmacokinetic Modeling of Bergamottin and 6,7‐Dihydroxybergamottin to Describe CYP3A4 Mediated Grapefruit‐Drug Interactions | Fuhr, Laura Maria; Marok, Fatima Zahra; Fuhr, Uwe; Selzer, Dominik; Lehr, Thorsten | |
| article | 2023 | Population pharmacokinetic modeling of multiple-dose intravenous fosfomycin in critically ill patients during continuous venovenous hemodialysis | Hüppe, Tobias; Götz, Katharina M.; Meiser, Andreas; de Faria Fernandes, Andrea; Maurer, Felix; Groesdonk, Heinrich V.; Volk, Thomas; Lehr, Thorsten; Kreuer, Sascha | |
| article | 2023 | Motivations for Adolescent COVID-19 Vaccination: A Comparative Study of Adolescent and Caregiver Perspectives in Germany | Rothoeft, Tobias; Brinkmann, Folke; Maier, Christoph; Selzer, Dominik; Dings, Christiane; Kuehn, Anna; Möhler, Eva; Grote, Hanna; Nonnenmacher, Alexandra; Wenning, Markus; Zemlin, Michael; Richter, Ulf; Lehr, Thorsten; Lücke, Thomas | |
| article | 2023 | A dynamic time‐to‐event model for prediction of acute graft‐versus‐host disease in patients after allogeneic hematopoietic stem cell transplantation | Och, Katharina; Turki, Amin T.; Götz, Katharina M.; Selzer, Dominik; Brossette, Christian; Theobald, Stefan; Braun, Yvonne; Graf, Norbert; Rauch, Jochen; Rohm, Kerstin; Weiler, Gabriele; Kiefer, Stephan; Schwarz, Ulf; Eisenberg, Lisa; Pfeifer, Nico; Ihle, Matthias; Grandjean, Andrea; Fix, Sonja; Riede, Claudia; Rissland, Jürgen; Smola, Sigrun; Beelen, Dietrich W.; Kaddu‐Mulindwa, Dominic; Bittenbring, Jörg; Lehr, Thorsten | |
| article | 2023 | Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug-drug-gene interaction network | Feick, Denise; Rüdesheim, Simeon; Marok, Fatima Zahra; Selzer, Dominik; Loer, Helena Leonie Hanae; Teutonico, Donato; Frechen, Sebastian; van der Lee, Maaike; Moes, Dirk Jan A. R.; Swen, Jesse J.; Schwab, Matthias; Lehr, Thorsten | |
| article | 2022 | Piloterhebung zur Fortbildungssituation der Apotheker*innen in Deutschland | Müller, Markus Alexander; Scholtes, Melanie Astrid; Louis, Chiara; Dörje, Frank; Lehr, Thorsten | |
| article | 2022 | A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug–Drug Interaction Modeling | Fuhr, Laura Maria; Marok, Fatima Zahra; Mees, Maximilian; Mahfoud, Felix; Selzer, Dominik; Lehr, Thorsten | |
| article | 2022 | Human papillomavirus vaccination of girls in the German model region Saarland: Insurance data-based analysis and identification of starting points for improving vaccination rates | Sternjakob-Marthaler, Anna; Berkó-Göttel, Barbara; Rissland, Jürgen; Schöpe, Jakob; Taurian, Emeline; Müller, Hanna; Weber, Gero; Lohse, Stefan; Lamberty, Thomas; Holleczek, Bernd; Stoffel, Harry; Hauptmann, Gunter; Giesen, Martin; Firk, Christiane; Schanzenbach, Alexandra; Brandt, Florian; Hohmann, Heike; Werthner, Quirin; Selzer, Dominik; Lehr, Thorsten; Wagenpfeil, Stefan; Smola, Sigrun | |
| article | 2022 | In Vitro–In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier | Kovar, Lukas; Wien, Lena; Selzer, Dominik; Kohl, Yvonne; Bals, Robert; Lehr, Thorsten | |
| article | 2022 | Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone | Rüdesheim, Simeon; Selzer, Dominik; Mürdter, Thomas; Igel, Svitlana; Kerb, Reinhold; Schwab, Matthias; Lehr, Thorsten | |
| article | 2022 | Physiologically-based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups | Rüdesheim, Simeon; Selzer, Dominik; Fuhr, Uwe; Schwab, Matthias; Lehr, Thorsten | |
| article | 2022 | Renal Transporter-Mediated Drug-Biomarker Interactions of the Endogenous Substrates Creatinine and N1 -Methylnicotinamide : A PBPK Modeling Approach | Türk, Denise; Müller, Fabian; Fromm, Martin F.; Selzer, Dominik; Dallmann, Robert; Lehr, Thorsten | |
| article | 2022 | Problematic Internet Use among Adolescents 18 Months after the Onset of the COVID-19 Pandemic | Paulus, Frank W.; Joas, Jens; Gerstner, Ida; Kühn, Anna; Wenning, Markus; Gehrke, Thomas; Burckhart, Holger; Richter, Ulf; Nonnenmacher, Alexandra; Zemlin, Michael; Lücke, Thomas; Brinkmann, Folke; Rothoeft, Tobias; Lehr, Thorsten; Möhler, Eva | |
| article | 2022 | Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients | Dings, Christiane; Meiser, Peter; Holzer, Frank; Flegel, Michael; Selzer, Dominik; Nagy, Eszter; Mösges, Ralph; Klussmann, Jens Peter; Lehr, Thorsten | |
| article | 2022 | Mental Health and Health-Related Quality of Life in German Adolescents after the Third Wave of the COVID-19 Pandemic | Hussong, Justine; Möhler, Eva; Kühn, Anna; Wenning, Markus; Gehrke, Thomas; Burckhart, Holger; Richter, Ulf; Nonnenmacher, Alexandra; Zemlin, Michael; Lücke, Thomas; Brinkmann, Folke; Rothoeft, Tobias; Lehr, Thorsten | |
| article | 2022 | Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug–Drug–Gene Interaction Predictions | Loer, Helena Leonie Hanae; Türk, Denise; Gómez-Mantilla, José David; Selzer, Dominik; Lehr, Thorsten | |
| article | 2021 | A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis | Van De Vyver, Arthur; Eigenmann, Miro; Ovacik, Meric; Pohl, Christian; Herter, Sylvia; Weinzierl, Tina; Fauti, Tanja; Klein, Christian; Lehr, Thorsten; Bacac, Marina; Walz, Antje-Christine | |
| article | 2021 | A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions | Frechen, Sebastian; Solodenko, Juri; Wendl, Thomas; Dallmann, André; Ince, Ibrahim; Lehr, Thorsten; Lippert, Jörg; Burghaus, Rolf | |
| article | 2021 | Cytokine Release Syndrome By T-cell-Redirecting Therapies : Can We Predict and Modulate Patient Risk? | Van De Vyver, Arthur J.; Marrer-Berger, Estelle; Wang, Ken; Lehr, Thorsten; Walz, Antje-Christine | |
| article | 2021 | Novel models for the prediction of drug-gene interactions | Türk, Denise; Fuhr, Laura Maria; Marok, Fatima Zahra; Rüdesheim, Simeon; Kühn, Anna; Selzer, Dominik; Schwab, Matthias; Lehr, Thorsten | |
| article | 2021 | Influence of Physicochemical Characteristics and Stability of Gold and Silver Nanoparticles on Biological Effects and Translocation across an Intestinal Barrier—A Case Study from In Vitro to In Silico | Kohl, Yvonne; Hesler, Michelle; Drexel, Roland; Kovar, Lukas; Dähnhardt-Pfeiffer, Stephan; Selzer, Dominik; Wagner, Sylvia; Lehr, Thorsten; von Briesen, Hagen; Meier, Florian | |
| article | 2021 | Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression : Combining In Vitro Experiments with Systems Modeling | Van De Vyver, Arthur J.; Weinzierl, Tina; Eigenmann, Miro J.; Frances, Nicolas; Herter, Sylvia; Buser, Regula B.; Somandin, Jitka; Diggelmann, Sarah; Limani, Florian; Lehr, Thorsten; Bacac, Marina; Walz, Antje-Christine | |
| article | 2021 | Toxicokinetics of U-47700, tramadol, and their main metabolites in pigs following intravenous administration: is a multiple species allometric scaling approach useful for the extrapolation of toxicokinetic parameters to humans? | Nordmeier, Frederike; Sihinevich, Iryna; Doerr, Adrian A.; Walle, Nadja; Laschke, Matthias W.; Lehr, Thorsten; Menger, Michael D.; Schmidt, Peter H.; Meyer, Markus R.; Schaefer, Nadine | |
| article | 2021 | External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease | Schräpel, Christina; Kovar, Lukas; Selzer, Dominik; Hofmann, Ute; Tran, Florian; Reinisch, Walter; Schwab, Matthias; Lehr, Thorsten | |
| article | 2021 | Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network | Marok, Fatima Zahra; Fuhr, Laura Maria; Hanke, Nina; Selzer, Dominik; Lehr, Thorsten | |
| article | 2021 | Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug–Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach | Fuhr, Laura Maria; Marok, Fatima Zahra; Hanke, Nina; Selzer, Dominik; Lehr, Thorsten | |
| article | 2020 | Exhaled Propofol Concentrations Correlate With Plasma and Brain Tissue Concentrations in Rats | Müller-Wirtz, Lukas M.; Maurer, Felix; Brausch, Timo; Kiefer, Daniel; Floss, Maximilian; Doneit, Jonas; Volk, Thomas; Sessler, Daniel I.; Fink, Tobias; Lehr, Thorsten; Kreuer, Sascha | |
| article | 2020 | Effect of an interprofessional care concept on the hospitalization of nursing home residents : study protocol for a cluster-randomized controlled trial | Piotrowski, Alexandra; Meyer, Martha; Burkholder, Iris; Renaud, Dagmar; Müller, Markus Alexander; Lehr, Thorsten; Laag, Sonja; Meiser, Joachim; Manderscheid, Lisa; Köberlein-Neu, Juliane | |
| article | 2020 | The federal standard medication plan in practice : An observational cross-sectional study on prevalence and quality | Mueller, Markus Alexander; Opitz, René; Grandt, Daniel; Lehr, Thorsten | |
| article | 2020 | Physiologically Based Precision Dosing Approach for Drug-Drug-Gene Interactions: A Simvastatin Network Analysis | Wojtyniak, Jan-Georg; Selzer, Dominik; Schwab, Matthias; Lehr, Thorsten | |
| article | 2020 | A Physiologically-Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP-1 and GIP and the DPP4 Inhibitor Sitagliptin | Balazki, Pavel; Schaller, Stephan; Eissing, Thomas; Lehr, Thorsten | |
| article | 2020 | Comprehensive Parent-Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies | Kovar, Lukas; Selzer, Dominik; Britz, Hannah; Benowitz, Neal; St. Helen, Gideon; Kohl, Yvonne; Bals, Robert; Lehr, Thorsten | |
| article | 2020 | Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling | Wojtyniak, Jan-Georg; Britz, Hannah; Selzer, Dominik; Schwab, Matthias; Lehr, Thorsten | |
| article | 2020 | Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis | Fuhr, Laura Maria; Hanke, Nina; Meibohm, Bernd; Lehr, Thorsten | |
| article | 2020 | Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions | Britz, Hannah; Hanke, Nina; Taub, Mitchell E.; Wang, Ting; Prasad, Bhagwat; Fernandez, Éric; Stopfer, Peter; Nock, Valerie; Lehr, Thorsten | |
| article | 2020 | Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions | Rüdesheim, Simeon; Wojtyniak, Jan-Georg; Selzer, Dominik; Hanke, Nina; Mahfoud, Felix; Schwab, Matthias; Lehr, Thorsten | |
| article | 2020 | A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions | Türk, Denise; Hanke, Nina; Lehr, Thorsten | |
| article | 2020 | Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients | Kovar, Lukas; Weber, Andreas; Zemlin, Michael; Kohl, Yvonne; Bals, Robert; Meibohm, Bernd; Selzer, Dominik; Lehr, Thorsten | |
| article | 2020 | A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug–Drug Interaction Studies | Hanke, Nina; Türk, Denise; Selzer, Dominik; Wiebe, Sabrina; Fernandez, Éric; Stopfer, Peter; Nock, Valerie; Lehr, Thorsten | |
| article | 2020 | Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates | Kovar, Lukas; Schräpel, Christina; Selzer, Dominik; Kohl, Yvonne; Bals, Robert; Schwab, Matthias; Lehr, Thorsten | |
| article | 2020 | A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals | Hanke, Nina; Türk, Denise; Selzer, Dominik; Ishiguro, Naoki; Ebner, Thomas; Wiebe, Sabrina; Müller, Fabian; Stopfer, Peter; Nock, Valerie; Lehr, Thorsten | |
| article | 2019 | A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug-Drug Interactions | Li, Xia; Frechen, Sebastian; Moj, Daniel; Lehr, Thorsten; Taubert, Max; Hsin, Chih-Hsuan; Mikus, Gerd; Neuvonen, Pertti J.; Olkkola, Klaus T.; Saari, Teijo I.; Fuhr, Uwe | |
| article | 2019 | Target-Mediated Population Pharmacokinetic Modeling of Endothelin Receptor Antagonists | Volz, Anke-Katrin; Dingemanse, Jasper; Krause, Andreas; Lehr, Thorsten | |
| article | 2019 | A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Model of Dabigatran Etexilate, Dabigatran and Dabigatran Glucuronide in Healthy Adults and Renally Impaired Patients | Moj, Daniel; Maas, Hugo; Schaeftlein, André; Hanke, Nina; Gómez-Mantilla, José David; Lehr, Thorsten | |
| article | 2019 | Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences | Lippert, Jörg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian; Karlsson, Mats; Kovar, Andreas; Lehr, Thorsten; Milligan, Peter; Nock, Valerie; Ramusovic, Sergej; Riggs, Matthew; Schaller, Stephan; Schlender, Jan; Schmidt, Stephan; Sevestre, Michaël; Sjögren, Erik; Solodenko, Juri; Staab, Alexander; Teutonico, Donato | |
| article | 2019 | Physiologically Based Pharmacokinetic Models for Prediction of Complex CYP2C8 and OATP1B1 (SLCO1B1) Drug-Drug-Gene Interactions : A Modeling Network of Gemfibrozil, Repaglinide, Pioglitazone, Rifampicin, Clarithromycin and Itraconazole | Türk, Denise; Hanke, Nina; Wolf, Sarah; Frechen, Sebastian; Eissing, Thomas; Wendl, Thomas; Schwab, Matthias; Lehr, Thorsten | |
| article | 2019 | Population Pharmacokinetics of Mefloquine Intermittent Preventive Treatment for Malaria in Pregnancy in Gabon | Ramharter, Michael; Schwab, Matthias; Mombo-Ngoma, Ghyslain; Zoleko Manego, Rella; Akerey-Diop, Daisy; Basra, Arti; Mackanga, Jean-Rodolphe; Würbel, Heike; Wojtyniak, Jan-Georg; Gonzalez, Raquel; Hofmann, Ute; Geditz, Mirjam; Matsiegui, Pierre-Blaise; Kremsner, Peter G.; Menendez, Clara; Kerb, Reinhold; Lehr, Thorsten | |
| article | 2019 | Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients | Hanke, Nina; Kunz, Claudia; Thiemann, Meinolf; Fricke, Harald; Lehr, Thorsten | |
| article | 2019 | Physiologically-Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam | Britz, Hannah; Hanke, Nina; Volz, Anke-Katrin; Spigset, Olav; Schwab, Matthias; Eissing, Thomas; Wendl, Thomas; Frechen, Sebastian; Lehr, Thorsten | |
| article | 2018 | Inhibition of Cyclin-Dependent Kinase 5 : A Strategy to Improve Sorafenib Response in Hepatocellular Carcinoma Therapy | Ardelt, Maximilian A.; Fröhlich, Thomas; Martini, Emanuele; Müller, Martin; Kanitz, Veronika; Atzberger, Carina; Cantonati, Petra; Meßner, Martina; Posselt, Laura; Lehr, Thorsten; Wojtyniak, Jan-Georg; Ulrich, Melanie; Arnold, Georg J.; König, Lars; Parazzoli, Dario; Zahler, Stefan; Rothenfußer, Simon; Mayr, Doris; Gerbes, Alexander; Scita, Giorgio; Vollmar, Angelika M.; Pachmayr, Johanna | |
| article | 2018 | A Quantitative Systems Pharmacology Kidney Model of Diabetes Associated Renal Hyperfiltration and the Effects of SGLT Inhibitors | Balazki, Pavel; Schaller, Stephan; Eissing, Thomas; Lehr, Thorsten | |
| article | 2018 | Can toxicokinetics of (synthetic) cannabinoids in pigs after pulmonary administration be upscaled to humans by allometric techniques? | Schaefer, Nadine; Wojtyniak, Jan-Georg; Kroell, Ann-Katrin; Koerbel, Christina; Laschke, Matthias W.; Lehr, Thorsten; Menger, Michael D.; Maurer, Hans H.; Meyer, Markus R.; Schmidt, Peter H. | |
| article | 2018 | Neovascular Age-Related Macular Degeneration : A Visual Acuity Model of Natural Disease Progression and Ranibizumab Treatment Effect | Mulyukov, Zufar; Weber, Sebastian; Pigeolet, Etienne; Clemens, Andreas; Lehr, Thorsten; Racine, Amy | |
| article | 2018 | PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin | Hanke, Nina; Frechen, Sebastian; Moj, Daniel; Britz, Hannah; Eissing, Thomas; Wendl, Thomas; Lehr, Thorsten | |
| article | 2018 | Population nutrikinetics of green tea extract | Scholl, Catharina; Lepper, Anna; Lehr, Thorsten; Hanke, Nina; Schneider, Katharina Luise; Brockmöller, Jürgen; Seufferlein, Thomas; Stingl, Julia Carolin | |
| article | 2018 | XplOit: An Ontology-Based Data Integration Platform Supporting the Development of Predictive Models for Personalized Medicine | Weiler, Gabriele; Schwarz, Ulf; Rauch, Jochen; Rohm, Kerstin; Lehr, Thorsten; Theobald, Stefan; Kiefer, Stephan; Götz, Katharina; Och, Katharina; Pfeifer, Nico; Handl, Lisa; Smola, Sigrun; Ihle, Matthias; Turki, Amin T.; Beelen, Dietrich W.; Rissland, Jürgen; Bittenbring, Jörg; Graf, Norbert | |
| article | 2017 | A physiologically based pharmacokinetic (PBPK) parent-metabolite model of the chemotherapeutic zoptarelin doxorubicin-integration of in vitro results, Phase I and Phase II data and model application for drug-drug interaction potential analysis | Hanke, Nina; Teifel, Michael; Moj, Daniel; Wojtyniak, Jan-Georg; Britz, Hannah; Aicher, Babette; Sindermann, Herbert; Ammer, Nicola; Lehr, Thorsten | |
| article | 2017 | How to disentangle psychobiological stress reactivity and recovery : A comparison of model-based and non-compartmental analyses of cortisol concentrations | Miller, Robert; Wojtyniak, Jan-Georg; Weckesser, Lisa J.; Alexander, Nina C.; Engert, Veronika; Lehr, Thorsten | |
| article | 2017 | Modeling Tolerance Development for the Effect on Heart Rate of the Selective S1P1 Receptor Modulator Ponesimod | Lott, Dominik; Lehr, Thorsten; Dingemanse, Jasper; Krause, Andreas | |
| article | 2017 | The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine | Schaefer, Nadine; Moj, Daniel; Lehr, Thorsten; Schmidt, Peter H.; Ramsthaler, Frank | |
| article | 2017 | A generic viral dynamic model to systematically characterize the interaction between oncolytic virus kinetics and tumor growth | Titze, Melanie I.; Frank, Julia; Ehrhardt, Michael; Smola, Sigrun; Graf, Norbert; Lehr, Thorsten | |
| article | 2017 | A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification | Moj, Daniel; Britz, Hannah; Burhenne, Jürgen; Stewart, Clinton F.; Egerer, Gerlinde; Haefeli, Walter E.; Lehr, Thorsten | |
| article | 2017 | Alternative Treatment Regimens With the PCSK9 Inhibitors Alirocumab and Evolocumab : A Pharmacokinetic and Pharmacodynamic Modeling Approach | Scherer, Nina; Dings, Christiane; Böhm, Michael; Laufs, Ulrich; Lehr, Thorsten | |
| article | 2017 | An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor | Titze, Melanie I.; Schaaf, Otmar; Hofmann, Marco H.; Sanderson, Michael P.; Zahn, Stephan K.; Quant, Jens; Lehr, Thorsten | |
| article | 2017 | Target-Mediated Drug Disposition Pharmacokinetic-Pharmacodynamic Model of Bosentan and Endothelin-1 | Volz, Anke-Katrin; Krause, Andreas; Haefeli, Walter Emil; Dingemanse, Jasper; Lehr, Thorsten | |
https://orcid.org/0000-0002-8372-1465