Please use this identifier to cite or link to this item:
doi:10.22028/D291-36397
Title: | German federal-state-wide seroprevalence study of 1st SARS-CoV-2 pandemic wave shows importance of long-term antibody test performance |
Author(s): | Lohse, Stefan Sternjakob-Marthaler, Anna Lagemann, Paul Schöpe, Jakob Rissland, Jürgen Seiwert, Nastasja Pfuhl, Thorsten Müllendorff, Alana Kiefer, Laurent S. Vogelgesang, Markus Vella, Luca Denk, Katharina Vicari, Julia Zwick, Anabel Lang, Isabelle Weber, Gero Geisel, Jürgen Rech, Jörg Schnabel, Bernd Hauptmann, Gunter Holleczek, Bernd Scheiblauer, Heinrich Wagenpfeil, Stefan Smola, Sigrun |
Language: | English |
Title: | Communications Medicine |
Volume: | 2 |
Issue: | 1 |
Publisher/Platform: | Springer Nature |
Year of Publication: | 2022 |
Free key words: | Population screening Viral infection |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Background Reliable data on the adult SARS-CoV-2 infection fatality rate in Germany are still scarce. We performed a federal state-wide cross-sectional seroprevalence study named SaarCoPS, that is representative for the adult population including elderly individuals and nursing home residents in the Saarland. Methods Serum was collected from 2940 adults via stationary or mobile teams during the 1st pandemic wave steady state period. We selected an antibody test system with maximal specificity, also excluding seroreversion effects due to a high longitudinal test performance. For the calculations of infection and fatality rates, we accounted for the delays of seroconversion and death after infection. Results Using a highly specific total antibody test detecting anti-SARS-CoV-2 responses over more than 180 days, we estimate an adult infection rate of 1.02% (95% CI: [0.64; 1.44]), an underreporting rate of 2.68-fold (95% CI: [1.68; 3.79]) and infection fatality rates of 2.09% (95% CI: (1.48; 3.32]) or 0.36% (95% CI: [0.25; 0.59]) in all adults including elderly individuals, or adults younger than 70 years, respectively. Conclusion The study highlights the importance of study design and test performance for seroprevalence studies, particularly when seroprevalences are low. Our results provide a valuable baseline for evaluation of future pandemic dynamics and impact of public health measures on virus spread and human health in comparison to neighbouring countries such as Luxembourg or France. |
DOI of the first publication: | 10.1038/s43856-022-00100-z |
URL of the first publication: | https://www.nature.com/articles/s43856-022-00100-z |
Link to this record: | urn:nbn:de:bsz:291--ds-363977 hdl:20.500.11880/33046 http://dx.doi.org/10.22028/D291-36397 |
ISSN: | 2730-664X |
Date of registration: | 8-Jun-2022 |
Description of the related object: | Supplementary information |
Related object: | https://static-content.springer.com/esm/art%3A10.1038%2Fs43856-022-00100-z/MediaObjects/43856_2022_100_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs43856-022-00100-z/MediaObjects/43856_2022_100_MOESM2_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs43856-022-00100-z/MediaObjects/43856_2022_100_MOESM3_ESM.xlsx https://static-content.springer.com/esm/art%3A10.1038%2Fs43856-022-00100-z/MediaObjects/43856_2022_100_MOESM4_ESM.pdf |
Faculty: | HW - Fakultät für Empirische Humanwissenschaften und Wirtschaftswissenschaft M - Medizinische Fakultät |
Department: | HW - Geographie M - Infektionsmedizin M - Innere Medizin M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professorship: | HW - Prof. Dr. Jochen Kubiniok M - Prof. Dr. Sigrun Smola M - Prof. Dr. Stefan Wagenpfeil M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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s43856-022-00100-z.pdf | 2,52 MB | Adobe PDF | View/Open |
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