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doi:10.22028/D291-36397
Titel: | German federal-state-wide seroprevalence study of 1st SARS-CoV-2 pandemic wave shows importance of long-term antibody test performance |
VerfasserIn: | Lohse, Stefan Sternjakob-Marthaler, Anna Lagemann, Paul Schöpe, Jakob Rissland, Jürgen Seiwert, Nastasja Pfuhl, Thorsten Müllendorff, Alana Kiefer, Laurent S. Vogelgesang, Markus Vella, Luca Denk, Katharina Vicari, Julia Zwick, Anabel Lang, Isabelle Weber, Gero Geisel, Jürgen Rech, Jörg Schnabel, Bernd Hauptmann, Gunter Holleczek, Bernd Scheiblauer, Heinrich Wagenpfeil, Stefan Smola, Sigrun |
Sprache: | Englisch |
Titel: | Communications Medicine |
Bandnummer: | 2 |
Heft: | 1 |
Verlag/Plattform: | Springer Nature |
Erscheinungsjahr: | 2022 |
Freie Schlagwörter: | Population screening Viral infection |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background Reliable data on the adult SARS-CoV-2 infection fatality rate in Germany are still scarce. We performed a federal state-wide cross-sectional seroprevalence study named SaarCoPS, that is representative for the adult population including elderly individuals and nursing home residents in the Saarland. Methods Serum was collected from 2940 adults via stationary or mobile teams during the 1st pandemic wave steady state period. We selected an antibody test system with maximal specificity, also excluding seroreversion effects due to a high longitudinal test performance. For the calculations of infection and fatality rates, we accounted for the delays of seroconversion and death after infection. Results Using a highly specific total antibody test detecting anti-SARS-CoV-2 responses over more than 180 days, we estimate an adult infection rate of 1.02% (95% CI: [0.64; 1.44]), an underreporting rate of 2.68-fold (95% CI: [1.68; 3.79]) and infection fatality rates of 2.09% (95% CI: (1.48; 3.32]) or 0.36% (95% CI: [0.25; 0.59]) in all adults including elderly individuals, or adults younger than 70 years, respectively. Conclusion The study highlights the importance of study design and test performance for seroprevalence studies, particularly when seroprevalences are low. Our results provide a valuable baseline for evaluation of future pandemic dynamics and impact of public health measures on virus spread and human health in comparison to neighbouring countries such as Luxembourg or France. |
DOI der Erstveröffentlichung: | 10.1038/s43856-022-00100-z |
URL der Erstveröffentlichung: | https://www.nature.com/articles/s43856-022-00100-z |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-363977 hdl:20.500.11880/33046 http://dx.doi.org/10.22028/D291-36397 |
ISSN: | 2730-664X |
Datum des Eintrags: | 8-Jun-2022 |
Bezeichnung des in Beziehung stehenden Objekts: | Supplementary information |
In Beziehung stehendes Objekt: | https://static-content.springer.com/esm/art%3A10.1038%2Fs43856-022-00100-z/MediaObjects/43856_2022_100_MOESM1_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs43856-022-00100-z/MediaObjects/43856_2022_100_MOESM2_ESM.pdf https://static-content.springer.com/esm/art%3A10.1038%2Fs43856-022-00100-z/MediaObjects/43856_2022_100_MOESM3_ESM.xlsx https://static-content.springer.com/esm/art%3A10.1038%2Fs43856-022-00100-z/MediaObjects/43856_2022_100_MOESM4_ESM.pdf |
Fakultät: | HW - Fakultät für Empirische Humanwissenschaften und Wirtschaftswissenschaft M - Medizinische Fakultät |
Fachrichtung: | HW - Geographie M - Infektionsmedizin M - Innere Medizin M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professur: | HW - Prof. Dr. Jochen Kubiniok M - Prof. Dr. Sigrun Smola M - Prof. Dr. Stefan Wagenpfeil M - Keiner Professur zugeordnet |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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s43856-022-00100-z.pdf | 2,52 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons