Please use this identifier to cite or link to this item: doi:10.22028/D291-36397
Title: German federal-state-wide seroprevalence study of 1st SARS-CoV-2 pandemic wave shows importance of long-term antibody test performance
Author(s): Lohse, Stefan
Sternjakob-Marthaler, Anna
Lagemann, Paul
Schöpe, Jakob
Rissland, Jürgen
Seiwert, Nastasja
Pfuhl, Thorsten
Müllendorff, Alana
Kiefer, Laurent S.
Vogelgesang, Markus
Vella, Luca
Denk, Katharina
Vicari, Julia
Zwick, Anabel
Lang, Isabelle
Weber, Gero
Geisel, Jürgen
Rech, Jörg
Schnabel, Bernd
Hauptmann, Gunter
Holleczek, Bernd
Scheiblauer, Heinrich
Wagenpfeil, Stefan
Smola, Sigrun
Language: English
Title: Communications Medicine
Volume: 2
Issue: 1
Publisher/Platform: Springer Nature
Year of Publication: 2022
Free key words: Population screening
Viral infection
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background Reliable data on the adult SARS-CoV-2 infection fatality rate in Germany are still scarce. We performed a federal state-wide cross-sectional seroprevalence study named SaarCoPS, that is representative for the adult population including elderly individuals and nursing home residents in the Saarland. Methods Serum was collected from 2940 adults via stationary or mobile teams during the 1st pandemic wave steady state period. We selected an antibody test system with maximal specificity, also excluding seroreversion effects due to a high longitudinal test performance. For the calculations of infection and fatality rates, we accounted for the delays of seroconversion and death after infection. Results Using a highly specific total antibody test detecting anti-SARS-CoV-2 responses over more than 180 days, we estimate an adult infection rate of 1.02% (95% CI: [0.64; 1.44]), an underreporting rate of 2.68-fold (95% CI: [1.68; 3.79]) and infection fatality rates of 2.09% (95% CI: (1.48; 3.32]) or 0.36% (95% CI: [0.25; 0.59]) in all adults including elderly individuals, or adults younger than 70 years, respectively. Conclusion The study highlights the importance of study design and test performance for seroprevalence studies, particularly when seroprevalences are low. Our results provide a valuable baseline for evaluation of future pandemic dynamics and impact of public health measures on virus spread and human health in comparison to neighbouring countries such as Luxembourg or France.
DOI of the first publication: 10.1038/s43856-022-00100-z
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-363977
ISSN: 2730-664X
Date of registration: 8-Jun-2022
Description of the related object: Supplementary information
Related object:
Faculty: HW - Fakultät für Empirische Humanwissenschaften und Wirtschaftswissenschaft
M - Medizinische Fakultät
Department: HW - Geographie
M - Infektionsmedizin
M - Innere Medizin
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professorship: HW - Prof. Dr. Jochen Kubiniok
M - Prof. Dr. Sigrun Smola
M - Prof. Dr. Stefan Wagenpfeil
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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