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Titel: Acanthocyte Sedimentation Rate as a Diagnostic Biomarker for Neuroacanthocytosis Syndromes: Experimental Evidence and Physical Justification
VerfasserIn: Darras, Alexis
Peikert, Kevin
Rabe, Antonia
Yaya, François
Simionato, Greta
John, Thomas
Dasanna, Anil Kumar
Buvalyy, Semen
Geisel, Jürgen
Hermann, Andreas
Fedosov, Dmitry A.
Danek, Adrian
Wagner, Christian
Kaestner, Lars
Sprache: Englisch
Titel: Cells
Bandnummer: 10
Heft: 4
Verlag/Plattform: MDPI
Erscheinungsjahr: 2021
Freie Schlagwörter: neuroacanthocytosis
erythrocyte sedimentation rate (ESR)
diagnosis
DDC-Sachgruppe: 500 Naturwissenschaften
530 Physik
610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: (1) Background: Chorea-acanthocytosis and McLeod syndrome are the core diseases among the group of rare neurodegenerative disorders called neuroacanthocytosis syndromes (NASs). NAS patients have a variable number of irregularly spiky erythrocytes, so-called acanthocytes. Their detection is a crucial but error-prone parameter in the diagnosis of NASs, often leading to misdiagnoses. (2) Methods: We measured the standard Westergren erythrocyte sedimentation rate (ESR) of various blood samples from NAS patients and healthy controls. Furthermore, we manipulated the ESR by swapping the erythrocytes and plasma of different individuals, as well as replacing plasma with dextran. These measurements were complemented by clinical laboratory data and single-cell adhesion force measurements. Additionally, we followed theoretical modeling approaches. (3) Results: We show that the acanthocyte sedimentation rate (ASR) with a two-hour read-out is significantly prolonged in chorea-acanthocytosis and McLeod syndrome without overlap compared to the ESR of the controls. Mechanistically, through modern colloidal physics, we show that acanthocyte aggregation and plasma fibrinogen levels slow down the sedimentation. Moreover, the inverse of ASR correlates with the number of acanthocytes (R 2 = 0.61, p = 0.004). (4) Conclusions: The ASR/ESR is a clear, robust and easily obtainable diagnostic marker. Independently of NASs, we also regard this study as a hallmark of the physical view of erythrocyte sedimentation by describing anticoagulated blood in stasis as a percolating gel, allowing the application of colloidal physics theory.
DOI der Erstveröffentlichung: 10.3390/cells10040788
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-339264
hdl:20.500.11880/31319
http://dx.doi.org/10.22028/D291-33926
ISSN: 2073-4409
Datum des Eintrags: 17-Mai-2021
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Materials
In Beziehung stehendes Objekt: https://www.mdpi.com/2073-4409/10/4/788/s1
Fakultät: M - Medizinische Fakultät
NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: M - Anatomie und Zellbiologie
M - Innere Medizin
NT - Physik
Professur: M - Keiner Professur zugeordnet
NT - Prof. Dr. Christian Wagner
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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