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doi:10.22028/D291-29437
Title: | MeDeCom: Discovery and Quantification of Latent Components of Heterogeneous Methylomes |
Author(s): | Lutsik, Pavlo Slawski, Martin Gasparoni, Gilles Vedeneev, Nikita Hein, Matthias Walter, Jörn Erik |
Language: | English |
Title: | Genome biology : biology for the post-genomic era |
Volume: | 18 |
Issue: | 1 |
Startpage: | 1 |
Endpage: | 20 |
Publisher/Platform: | BioMed Central |
Year of Publication: | 2017 |
Publikation type: | Journal Article |
Abstract: | It is important for large-scale epigenomic studies to determine and explore the nature of hidden confounding variation, most importantly cell composition. We developed MeDeCom as a novel reference-free computational framework that allows the decomposition of complex DNA methylomes into latent methylation components and their proportions in each sample. MeDeCom is based on constrained non-negative matrix factorization with a new biologically motivated regularization function. It accurately recovers cell-type-specific latent methylation components and their proportions. MeDeCom is a new unsupervised tool for the exploratory study of the major sources of methylation variation, which should lead to a deeper understanding and better biological interpretation. |
DOI of the first publication: | 10.1186/s13059-017-1182-6 |
URL of the first publication: | https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1182-6 |
Link to this record: | hdl:20.500.11880/27893 http://dx.doi.org/10.22028/D291-29437 |
ISSN: | 1465-6914 1474-760X |
Date of registration: | 25-Sep-2019 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Biowissenschaften |
Professorship: | NT - Prof. Dr. Jörn Walter |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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