Please use this identifier to cite or link to this item: doi:10.22028/D291-29437
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Title: MeDeCom: Discovery and Quantification of Latent Components of Heterogeneous Methylomes
Author(s): Lutsik, Pavlo
Slawski, Martin
Gasparoni, Gilles
Vedeneev, Nikita
Hein, Matthias
Walter, Jörn Erik
Language: English
Title: Genome biology : biology for the post-genomic era
Volume: 18
Issue: 1
Startpage: 1
Endpage: 20
Publisher/Platform: BioMed Central
Year of Publication: 2017
Publikation type: Journal Article
Abstract: It is important for large-scale epigenomic studies to determine and explore the nature of hidden confounding variation, most importantly cell composition. We developed MeDeCom as a novel reference-free computational framework that allows the decomposition of complex DNA methylomes into latent methylation components and their proportions in each sample. MeDeCom is based on constrained non-negative matrix factorization with a new biologically motivated regularization function. It accurately recovers cell-type-specific latent methylation components and their proportions. MeDeCom is a new unsupervised tool for the exploratory study of the major sources of methylation variation, which should lead to a deeper understanding and better biological interpretation.
DOI of the first publication: 10.1186/s13059-017-1182-6
URL of the first publication:
Link to this record: hdl:20.500.11880/27893
ISSN: 1465-6914
Date of registration: 25-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Jörn Walter
Collections:Die Universitätsbibliographie

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