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|Title:||MeDeCom : discovery and quantification of latent components of heterogeneous methylomes|
Walter, Jörn Erik
|Year of Publication:||2017|
|Publikation type:||Journal Article|
|Abstract:||It is important for large-scale epigenomic studies to determine and explore the nature of hidden confounding variation, most importantly cell composition. We developed MeDeCom as a novel reference-free computational framework that allows the decomposition of complex DNA methylomes into latent methylation components and their proportions in each sample. MeDeCom is based on constrained non-negative matrix factorization with a new biologically motivated regularization function. It accurately recovers cell-type-specific latent methylation components and their proportions. MeDeCom is a new unsupervised tool for the exploratory study of the major sources of methylation variation, which should lead to a deeper understanding and better biological interpretation.|
|DOI of the first publication:||10.1186/s13059-017-1182-6|
|Link to this record:||hdl:20.500.11880/27893|
|Date of registration:||25-Sep-2019|
|Faculty:||NT - Naturwissenschaftlich- Technische Fakultät|
|Department:||NT - Biowissenschaften|
|Collections:||UniBib – Die Universitätsbibliographie|
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