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doi:10.22028/D291-28711
Title: | Strand-seq enables reliable separation of long reads by chromosome via expectation maximization |
Author(s): | Ghareghani, Maryam Porubskỳ, David Sanders, Ashley D. Meiers, Sascha Eichler, Evan E. Korbel, Jan O. Marschall, Tobias |
Language: | English |
Title: | Bioinformatics |
Volume: | 34 |
Issue: | 13 |
Startpage: | 115 |
Endpage: | 123 |
Publisher/Platform: | Oxford University Press |
Year of Publication: | 2018 |
Publikation type: | Journal Article |
Abstract: | Current sequencing technologies are able to produce reads orders of magnitude longer than ever possible before. Such long reads have sparked a new interest in de novo genome assembly, which removes reference biases inherent to re-sequencing approaches and allows for a direct characterization of complex genomic variants. However, even with latest algorithmic advances, assembling a mammalian genome from long error-prone reads incurs a significant computational burden and does not preclude occasional misassemblies. Both problems could potentially be mitigated if assembly could commence for each chromosome separately. |
DOI of the first publication: | 10.1093/bioinformatics/bty290 |
Link to this record: | hdl:20.500.11880/27711 http://dx.doi.org/10.22028/D291-28711 |
ISSN: | 1367-4803 1460-2059 |
Date of registration: | 7-Sep-2019 |
Faculty: | MI - Fakultät für Mathematik und Informatik |
Department: | MI - Informatik |
Professorship: | MI - Prof. Dr. Tobias Marschall |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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