Please use this identifier to cite or link to this item: doi:10.22028/D291-28711
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Title: Strand-seq enables reliable separation of long reads by chromosome via expectation maximization
Author(s): Ghareghani, Maryam
Porubskỳ, David
Sanders, Ashley D.
Meiers, Sascha
Eichler, Evan E.
Korbel, Jan O.
Marschall, Tobias
Language: English
Title: Bioinformatics
Volume: 34
Issue: 13
Startpage: 115
Endpage: 123
Publisher/Platform: Oxford University Press
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Current sequencing technologies are able to produce reads orders of magnitude longer than ever possible before. Such long reads have sparked a new interest in de novo genome assembly, which removes reference biases inherent to re-sequencing approaches and allows for a direct characterization of complex genomic variants. However, even with latest algorithmic advances, assembling a mammalian genome from long error-prone reads incurs a significant computational burden and does not preclude occasional misassemblies. Both problems could potentially be mitigated if assembly could commence for each chromosome separately.
DOI of the first publication: 10.1093/bioinformatics/bty290
Link to this record: hdl:20.500.11880/27711
ISSN: 1367-4803
Date of registration: 7-Sep-2019
Faculty: MI - Fakultät für Mathematik und Informatik
Department: MI - Informatik
Professorship: MI - Prof. Dr. Tobias Marschall
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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