Aging affects the mechanical interaction between microplastics and lipid bilayers

Abstract

Plastic pellets, the pre-production form of many plastic products, undergo oxidation and photodegradation upon exposure to oxygen and sunlight, resulting in visible color changes. This study examines the impact of environmental aging on the mechanical interactions between pellet-derived microplastics and lipid bilayers, a critical component of biological membranes. Polyethylene pellets were collected from La Pineda beach near Tarragona, Spain, and categorized by chemical composition and yellowing index, an indicator of aging. The hydrophilicity of these pellets was assessed using contact angle measurements. Microplastics were produced by grinding and filtering these pellets and subsequently dispersed around a free-standing lipid bilayer within a 3D microfluidic chip to investigate their interactions. Our results reveal that aged microplastics exhibit a significantly increased adhesive interaction with lipid bilayers, leading to greater bilayer stretching. Theoretical modeling indicates a linear relationship between the adhesive interaction and the contact angle of the pellets, reflecting their hydrophilicity. These findings emphasize the increased mechanical impact of aged microplastics on biological membranes, which raises concerns about their potential toxicological effects on living organisms. This study highlights the importance of understanding the interactions between environmentally aged microplastics and biological systems to assess their risks, as these may differ significantly from pristine microplastics often studied under laboratory conditions.