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doi:10.22028/D291-44232 | Title: | PNPLA3 p.I148M and TM6SF2 p.E167K variants do not predispose to liver injury in cholestatic liver diseases: A prospective analysis of 178 patients with PSC |
| Author(s): | Kruk, Beata Liebe, Roman Milkiewicz, Małgorzata Wunsch, Ewa Raszeja-Wyszomirska, Joanna Lammert, Frank  Milkiewicz, Piotr Krawczyk, Marcin Jan |
| Language: | English |
| In: | |
| Title: | PLOS ONE |
| Volume: | 13 |
| Issue: | 8 |
| Publisher/Platform: | PLOS |
| Year of Publication: | 2018 |
| DDC notations: | 610 Medicine and health |
| Publikation type: | Journal Article |
| Abstract: | The adiponutrin (PNPLA3) p.I148M and transmembrane 6 superfamily member 2 (TM6SF2) p.E167K variants represent major genetic risk factors for progressive liver injury in nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) and chronic viral hepatitis. The aim of this study was to find out whether these variants have a detrimental impact on the progression of chronic liver disease in patients with prolonged cholestasis induced by primary sclerosing cholangitis (PSC). |
| DOI of the first publication: | 10.1371/journal.pone.0202942 |
| URL of the first publication: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202942 |
| Link to this record: | urn:nbn:de:bsz:291--ds-442327 hdl:20.500.11880/39564 http://dx.doi.org/10.22028/D291-44232 |
| ISSN: | 1932-6203 |
| Date of registration: | 4-Feb-2025 |
| Faculty: | M - Medizinische Fakultät |
| Department: | M - Innere Medizin |
| Professorship: | M - Prof. Dr. Frank Lammert M - Keiner Professur zugeordnet |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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