Please use this identifier to cite or link to this item:
doi:10.22028/D291-43632 | Title: | Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli |
| Author(s): | Deschner, Felix Risch, Timo Baier, Claas Schlüter, Dirk Herrmann, Jennifer Müller, Rolf |
| Language: | English |
| Title: | Microbiology spectrum |
| Volume: | 12 |
| Issue: | 1 |
| Publisher/Platform: | ASM |
| Year of Publication: | 2023 |
| Free key words: | nitroxoline antibiotic resistance fitness virulence proteomics metabolism genome analysis urinary tract infection |
| DDC notations: | 500 Science |
| Publikation type: | Journal Article |
| Abstract: | Antimicrobial resistance (AMR) poses a global threat and requires the exploration of underestimated treatment options. Nitroxoline, an effective broad-spectrum antibiotic, does not suffer from high resistance rates in the clinics but surprisingly, it is not heavily used yet. Our findings provide compelling evidence that Nitroxoline resistance renders bacteria unable to cause an infection in vivo, thereby reinvigorating the potential of Nitroxoline in combating AMR. |
| DOI of the first publication: | 10.1128/spectrum.03079-23 |
| URL of the first publication: | https://journals.asm.org/doi/10.1128/spectrum.03079-23 |
| Link to this record: | urn:nbn:de:bsz:291--ds-436324 hdl:20.500.11880/39092 http://dx.doi.org/10.22028/D291-43632 |
| ISSN: | 2165-0497 |
| Date of registration: | 2-Dec-2024 |
| Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
| Department: | NT - Pharmazie |
| Professorship: | NT - Prof. Dr. Rolf Müller |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| deschner-et-al-2023-nitroxoline-resistance-is-associated-with-significant-fitness-loss-and-diminishes-in-vivo-virulence.pdf | 2,05 MB | Adobe PDF | View/Open |
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