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doi:10.22028/D291-43352 | Title: | Synthesis of HC-Toxin via Matteson Homologation and C-H Functionalization |
| Author(s): | Kohr, Michael Kazmaier, Uli |
| Language: | English |
| Title: | The Journal of Organic Chemistry |
| Volume: | 88 |
| Issue: | 15 |
| Pages: | 10869-10880 |
| Publisher/Platform: | ACS |
| Year of Publication: | 2023 |
| Free key words: | Anions Mixtures Organic Compounds Peptides And Proteins Solutions |
| DDC notations: | 500 Science |
| Publikation type: | Journal Article |
| Abstract: | A new synthetic route toward host-specific HC-toxin was developed. The HC-toxin belongs to a group of cyclic, tetrapeptide histone deacetylase inhibitors containing the unusual amino acid Aeo. Key steps in the synthesis of this building block include the Matteson homologation to generate the stereogenic centers in the side chain and a C−H functionalization to connect the side chain to a protected alanine. |
| DOI of the first publication: | 10.1021/acs.joc.3c00914 |
| URL of the first publication: | https://pubs.acs.org/doi/10.1021/acs.joc.3c00914 |
| Link to this record: | urn:nbn:de:bsz:291--ds-433529 hdl:20.500.11880/38885 http://dx.doi.org/10.22028/D291-43352 |
| ISSN: | 1520-6904 0022-3263 |
| Date of registration: | 5-Nov-2024 |
| Description of the related object: | Supporting Information |
| Related object: | https://ndownloader.figstatic.com/files/41557948 |
| Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
| Department: | NT - Chemie |
| Professorship: | NT - Prof. Dr. Uli Kazmaier |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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