Please use this identifier to cite or link to this item: doi:10.22028/D291-42480
Title: Benzanthric Acid, a Novel Metabolite From Streptomyces albus Del14 Expressing the Nybomycin Gene Cluster
Author(s): Rodríguez Estévez, Marta
Gummerlich, Nils
Myronovskyi, Maksym
Zapp, Josef
Luzhetskyy, Andriy
Language: English
Title: Frontiers in Chemistry
Volume: 7
Publisher/Platform: Frontiers
Year of Publication: 2020
Free key words: benzanthric acid
biosynthetic gene cluster
heterologous expression
nybomycin
secondary metabolite
Streptomyces
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: Streptomycetes constitute a diverse bacterial group able to produce a wide variety of secondary metabolites with potential applications in the pharmacy industry. However, the genes responsible for the biosynthesis of these compounds are very frequently inactive or expressed at very low levels under standard laboratory cultivation conditions. Therefore, the activation or upregulation of secondary metabolite biosynthesis genes is a crucial step for the discovery of new bioactive natural products. We have recently reported the discovery of the biosynthetic genes for the antibiotic nybomycin (nyb genes) in Streptomyces albus subsp. chlorinus. The nyb genes were expressed in the heterologous host Streptomyces albus Del14, which produces not only nybomycin, but also a novel compound. In this study, we describe the isolation, purification, and structure elucidation of the new substance named benzanthric acid.
DOI of the first publication: 10.3389/fchem.2019.00896
URL of the first publication: https://doi.org/10.3389/fchem.2019.00896
Link to this record: urn:nbn:de:bsz:291--ds-424805
hdl:20.500.11880/38123
http://dx.doi.org/10.22028/D291-42480
ISSN: 2296-2646
Date of registration: 30-Jul-2024
Description of the related object: Supplementary Material
Related object: https://www.frontiersin.org/api/v3/articles/495873/file/Table_1.DOCX/495873_supplementary-materials_tables_1_docx/1?isPublishedV2=false
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Alexandra K. Kiemer
NT - Prof. Dr. Andriy Luzhetskyy
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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