Please use this identifier to cite or link to this item:
doi:10.22028/D291-42480
Title: | Benzanthric Acid, a Novel Metabolite From Streptomyces albus Del14 Expressing the Nybomycin Gene Cluster |
Author(s): | Rodríguez Estévez, Marta Gummerlich, Nils Myronovskyi, Maksym Zapp, Josef Luzhetskyy, Andriy |
Language: | English |
Title: | Frontiers in Chemistry |
Volume: | 7 |
Publisher/Platform: | Frontiers |
Year of Publication: | 2020 |
Free key words: | benzanthric acid biosynthetic gene cluster heterologous expression nybomycin secondary metabolite Streptomyces |
DDC notations: | 500 Science |
Publikation type: | Journal Article |
Abstract: | Streptomycetes constitute a diverse bacterial group able to produce a wide variety of secondary metabolites with potential applications in the pharmacy industry. However, the genes responsible for the biosynthesis of these compounds are very frequently inactive or expressed at very low levels under standard laboratory cultivation conditions. Therefore, the activation or upregulation of secondary metabolite biosynthesis genes is a crucial step for the discovery of new bioactive natural products. We have recently reported the discovery of the biosynthetic genes for the antibiotic nybomycin (nyb genes) in Streptomyces albus subsp. chlorinus. The nyb genes were expressed in the heterologous host Streptomyces albus Del14, which produces not only nybomycin, but also a novel compound. In this study, we describe the isolation, purification, and structure elucidation of the new substance named benzanthric acid. |
DOI of the first publication: | 10.3389/fchem.2019.00896 |
URL of the first publication: | https://doi.org/10.3389/fchem.2019.00896 |
Link to this record: | urn:nbn:de:bsz:291--ds-424805 hdl:20.500.11880/38123 http://dx.doi.org/10.22028/D291-42480 |
ISSN: | 2296-2646 |
Date of registration: | 30-Jul-2024 |
Description of the related object: | Supplementary Material |
Related object: | https://www.frontiersin.org/api/v3/articles/495873/file/Table_1.DOCX/495873_supplementary-materials_tables_1_docx/1?isPublishedV2=false |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Alexandra K. Kiemer NT - Prof. Dr. Andriy Luzhetskyy |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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fchem-07-00896.pdf | 635,01 kB | Adobe PDF | View/Open |
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