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doi:10.22028/D291-41682
Title: | Discovery of a high-performance phage-derived promoter/repressor system for probiotic lactobacillus engineering |
Author(s): | Blanch-Asensio, Marc Tadimarri, Varun Sai Wilk, Alina Sankaran, Shrikrishnan |
Language: | English |
Title: | Microbial cell factories |
Volume: | 23 |
Issue: | 1 |
Publisher/Platform: | Biomed Central |
Year of Publication: | 2024 |
DDC notations: | 570 Life sciences, biology |
Publikation type: | Journal Article |
Abstract: | The Lactobacillaceae family comprises many species of great importance for the food and healthcare industries, with numerous strains identified as beneficial for humans and used as probiotics. Hence, there is a growing interest in engineering these probiotic bacteria as live biotherapeutics for animals and humans. However, the genetic parts needed to regulate gene expression in these bacteria remain limited compared to model bacteria like E. coli or B. subtilis. To address this deficit, in this study, we selected and tested several bacteriophage-derived genetic parts with the potential to regulate transcription in lactobacilli. |
DOI of the first publication: | 10.1186/s12934-024-02302-7 |
URL of the first publication: | https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-024-02302-7 |
Link to this record: | urn:nbn:de:bsz:291--ds-416823 hdl:20.500.11880/37509 http://dx.doi.org/10.22028/D291-41682 |
ISSN: | 1475-2859 |
Date of registration: | 22-Apr-2024 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Biowissenschaften |
Professorship: | NT - Prof. Dr. Aránzazu del Campo |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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