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doi:10.22028/D291-41642
Title: | An engineered surrogate poly(A) tail to wag translation initiation |
Author(s): | Lohse, Stefan Weber, Wilfried |
Language: | English |
Title: | Cell research |
Volume: | 34 |
Issue: | 2 |
Pages: | 95-96 |
Publisher/Platform: | Springer Nature |
Year of Publication: | 2024 |
DDC notations: | 570 Life sciences, biology |
Publikation type: | Journal Article |
Abstract: | A novel approach for controlling translation initiation in mammalian cells is demonstrated based on the conditional attachment of eukaryotic translation initiation factor-binding proteins to the 3′ UTR of mRNAs via small molecule-, light-, or protein-responsive interactions. The technology overcomes limitations of previously used transcription-based switches and was shown to be functional in managing diabetes or tumor growth in preclinical animal models. |
DOI of the first publication: | 10.1038/s41422-023-00903-2 |
URL of the first publication: | https://www.nature.com/articles/s41422-023-00903-2 |
Link to this record: | urn:nbn:de:bsz:291--ds-416429 hdl:20.500.11880/37503 http://dx.doi.org/10.22028/D291-41642 |
ISSN: | 1748-7838 1001-0602 |
Date of registration: | 19-Apr-2024 |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Biowissenschaften |
Professorship: | NT - Prof. Dr. Wilfried Weber |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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