Please use this identifier to cite or link to this item: doi:10.22028/D291-41642
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Title: An engineered surrogate poly(A) tail to wag translation initiation
Author(s): Lohse, Stefan
Weber, Wilfried
Language: English
Title: Cell research
Volume: 34
Issue: 2
Pages: 95-96
Publisher/Platform: Springer Nature
Year of Publication: 2024
DDC notations: 570 Life sciences, biology
Publikation type: Journal Article
Abstract: A novel approach for controlling translation initiation in mammalian cells is demonstrated based on the conditional attachment of eukaryotic translation initiation factor-binding proteins to the 3′ UTR of mRNAs via small molecule-, light-, or protein-responsive interactions. The technology overcomes limitations of previously used transcription-based switches and was shown to be functional in managing diabetes or tumor growth in preclinical animal models.
DOI of the first publication: 10.1038/s41422-023-00903-2
URL of the first publication: https://www.nature.com/articles/s41422-023-00903-2
Link to this record: urn:nbn:de:bsz:291--ds-416429
hdl:20.500.11880/37503
http://dx.doi.org/10.22028/D291-41642
ISSN: 1748-7838
1001-0602
Date of registration: 19-Apr-2024
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Wilfried Weber
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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