Please use this identifier to cite or link to this item:
doi:10.22028/D291-41700
Title: | DIGGER: exploring the functional role of alternative splicing in protein interactions |
Author(s): | Louadi, Zakaria Yuan, Kevin Gress, Alexander Tsoy, Olga Kalinina, Olga V. Baumbach, Jan Kacprowski, Tim List, Markus |
Language: | English |
Title: | Nucleic Acids Research |
Volume: | 49 (2021) |
Issue: | D1 |
Pages: | D309-D318 |
Publisher/Platform: | Oxford University Press |
Year of Publication: | 2020 |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing. |
DOI of the first publication: | 10.1093/nar/gkaa768 |
URL of the first publication: | https://doi.org/10.1093/nar/gkaa768 |
Link to this record: | urn:nbn:de:bsz:291--ds-417006 hdl:20.500.11880/37324 http://dx.doi.org/10.22028/D291-41700 |
ISSN: | 1362-4962 0305-1048 |
Date of registration: | 4-Mar-2024 |
Description of the related object: | Supplementary Data |
Related object: | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/nar/49/D1/10.1093_nar_gkaa768/1/gkaa768_supplemental_file.pdf?Expires=1712562660&Signature=stItjASEM9W-WdISHH-pssCCp-2-chPVQQrN3KmLJ9D2rdwaovqlrj6I7i~F4UgByvpU0gI9AhmT8MqA62EVb37I0mf8wP6iVm7REKEqyl4yyJXVIEwqFdsDKEKAlIjIC9oUJ4e4Cicpq9EjEFAaQrKj1PCTg~XqKCudEgT7Hq~B6ugSZspuHru6lmgFfCCt1Ie8bmeMPTdzOqSnffdSzZ7ldJTsOazU2cBbhnbGXg2hkRnzRVGmUjoXff5heERYj~mxJBH46OMqfosOacdlhgq3SYzRybWJV6R5L1dVGJF2Aer4OLqU9pkcD7vY8DiP610AvqcvvkwN9hlKAYrPrw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA |
Faculty: | M - Medizinische Fakultät |
Department: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professorship: | M - Prof. Dr. Olga Kalinina |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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gkaa768.pdf | 3,41 MB | Adobe PDF | View/Open |
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