Please use this identifier to cite or link to this item: doi:10.22028/D291-41700
Title: DIGGER: exploring the functional role of alternative splicing in protein interactions
Author(s): Louadi, Zakaria
Yuan, Kevin
Gress, Alexander
Tsoy, Olga
Kalinina, Olga V.
Baumbach, Jan
Kacprowski, Tim
List, Markus
Language: English
Title: Nucleic Acids Research
Volume: 49 (2021)
Issue: D1
Pages: D309-D318
Publisher/Platform: Oxford University Press
Year of Publication: 2020
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing.
DOI of the first publication: 10.1093/nar/gkaa768
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-417006
ISSN: 1362-4962
Date of registration: 4-Mar-2024
Description of the related object: Supplementary Data
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Professorship: M - Prof. Dr. Olga Kalinina
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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