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doi:10.22028/D291-40614
Titel: | Characteristics and outcome of pediatric renal cell carcinoma patients registered in the International Society of Pediatric Oncology (SIOP) 93-01, 2001 and UK-IMPORT database: A report of the SIOP-Renal Tumor Study Group |
VerfasserIn: | van der Beek, Justine N. Hol, Janna A. Coulomb-l'Hermine, Aurore Graf, Norbert van Tinteren, Harm Pritchard-Jones, Kathy Houwing, Maite E. de Krijger, Ronald R. Vujanic, Gordan M. Dzhuma, Kristina Schenk, Jens-Peter Littooij, Annemieke S. Ramírez-Villar, Gema L. Murphy, Dermot Ray, Satyajit Al-Saadi, Reem Gessler, Manfred Godzinski, Jan Ruebe, Christian Collini, Paola Verschuur, Arnaud C. Frisk, Tony Vokuhl, Christian Hulsbergen-van de Kaa, Christina A. de Camargo, Beatriz Sandstedt, Bengt Selle, Barbara Tytgat, Godelieve A. M. van den Heuvel-Eibrink, Marry M. |
Sprache: | Englisch |
Titel: | International Journal of Cancer |
Bandnummer: | 148 |
Heft: | 11 |
Seiten: | 2724-2735 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2021 |
Freie Schlagwörter: | pediatric renal cell carcinoma survival treatment |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93-01, 2001 and UK-IMPORT databases, were included. Event-free survival (EFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Between 1993 and 2019, 122 pediatric patients with RCC were registered. Available detailed data (n = 111) revealed 56 localized, 30 regionally advanced, 25 metastatic and no bilateral cases. Histological classification according to World Health Organization 2004, including immunohistochemical and molecular testing for transcription factor E3 (TFE3) and/or EB (TFEB) translocation, was available for 65/122 patients. In this group, the most common histological subtypes were translocation type RCC (MiT-RCC) (36/64, 56.3%), papillary type (19/64, 29.7%) and clear cell type (4/64, 6.3%). One histological subtype was not reported. In the remaining 57 patients, translocation testing could not be performed, or TFE-cytogenetics and/or immunohistochemistry results were missing. In this group, the most common RCC histological subtypes were papillary type (21/47, 44.7%) and clear cell type (11/47, 23.4%). Ten histological subtypes were not reported. Estimated 5-year (5y) EFS and 5y OS of the total group was 70.5% (95% CI = 61.7%- 80.6%) and 84.5% (95% CI = 77.5%-92.2%), respectively. Estimated 5y OS for localized, regionally advanced, and metastatic disease was 96.8%, 92.3%, and 45.6%, respectively. In conclusion, the registered pediatric patients with RCC showed a reasonable outcome. Survival was substantially lower for patients with metastatic disease. This descriptive study stresses the importance of full, prospective registration including TFE-testing. |
DOI der Erstveröffentlichung: | 10.1002/ijc.33476 |
URL der Erstveröffentlichung: | https://doi.org/10.1002/ijc.33476 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-406141 hdl:20.500.11880/36492 http://dx.doi.org/10.22028/D291-40614 |
ISSN: | 1097-0215 0020-7136 |
Datum des Eintrags: | 27-Sep-2023 |
Bezeichnung des in Beziehung stehenden Objekts: | Supporting Information |
In Beziehung stehendes Objekt: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fijc.33476&file=ijc33476-sup-0001-supinfo.pdf |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Pädiatrie M - Radiologie |
Professur: | M - Prof. Dr. Norbert Graf M - Prof. Dr. Christian Rübe |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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Intl Journal of Cancer - 2021 - Beek.pdf | 1,23 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons