Please use this identifier to cite or link to this item:
doi:10.22028/D291-40208
Title: | Progressive Cerebral Small Vessel Disease Caused by an Autoimmune Response to Intravesical Bacille-Calmette-Guérin Treatment |
Author(s): | Becker, Anouck Grunwald, Iris Quasar Unger, Marcus M. Behnke, Stefanie Spiegel, Joerg Yilmaz, Umut Walter, Silke Faßbender, Klaus |
Language: | English |
Title: | Frontiers in Neurology |
Volume: | 11 |
Publisher/Platform: | Frontiers |
Year of Publication: | 2020 |
Free key words: | cerebral vasculitis small vessel disease BCG Bacille-Calmette-Guerin (BCG) autoimmune disease urothelioma molecular mimicry |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Systemic BCGitis and autoimmune diseases are possible adverse events of intravesical Bacille Calmette-Guérin-(BCG)-instillations in the treatment of urothelioma cancer. We present the case of an 83-years-old male patient with rapid progressive symptoms of dementia up to mutism as well as tonic seizures. Immune-mediated cerebral small vessel disease was diagnosed and retraced to former instillations of BCG. Intense immunosuppressive treatment was performed and clinical restoration was achieved within several months. While cerebral vasculitis due to BCGitis has already been described before, this is to our knowledge the first case report to illustrate an immune-mediated small vessel disease after BCG-instillations. This should be considered in patients with rapidly progressive dementia-like symptoms treated with BCG, as an immunosuppressive treatment can be highly effective even at severe clinical stages. |
DOI of the first publication: | 10.3389/fneur.2020.484282 |
URL of the first publication: | https://www.frontiersin.org/articles/10.3389/fneur.2020.484282 |
Link to this record: | urn:nbn:de:bsz:291--ds-402088 hdl:20.500.11880/36166 http://dx.doi.org/10.22028/D291-40208 |
ISSN: | 1664-2295 |
Date of registration: | 26-Jul-2023 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Neurologie und Psychiatrie M - Radiologie |
Professorship: | M - Prof. Dr. Klaus Faßbender M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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