Please use this identifier to cite or link to this item: doi:10.22028/D291-40208
Title: Progressive Cerebral Small Vessel Disease Caused by an Autoimmune Response to Intravesical Bacille-Calmette-Guérin Treatment
Author(s): Becker, Anouck
Grunwald, Iris Quasar
Unger, Marcus M.
Behnke, Stefanie
Spiegel, Joerg
Yilmaz, Umut
Walter, Silke
Faßbender, Klaus
Language: English
Title: Frontiers in Neurology
Volume: 11
Publisher/Platform: Frontiers
Year of Publication: 2020
Free key words: cerebral vasculitis
small vessel disease
Bacille-Calmette-Guerin (BCG)
autoimmune disease
molecular mimicry
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Systemic BCGitis and autoimmune diseases are possible adverse events of intravesical Bacille Calmette-Guérin-(BCG)-instillations in the treatment of urothelioma cancer. We present the case of an 83-years-old male patient with rapid progressive symptoms of dementia up to mutism as well as tonic seizures. Immune-mediated cerebral small vessel disease was diagnosed and retraced to former instillations of BCG. Intense immunosuppressive treatment was performed and clinical restoration was achieved within several months. While cerebral vasculitis due to BCGitis has already been described before, this is to our knowledge the first case report to illustrate an immune-mediated small vessel disease after BCG-instillations. This should be considered in patients with rapidly progressive dementia-like symptoms treated with BCG, as an immunosuppressive treatment can be highly effective even at severe clinical stages.
DOI of the first publication: 10.3389/fneur.2020.484282
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-402088
ISSN: 1664-2295
Date of registration: 26-Jul-2023
Faculty: M - Medizinische Fakultät
Department: M - Neurologie und Psychiatrie
M - Radiologie
Professorship: M - Prof. Dr. Klaus Faßbender
M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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