Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen:
Volltext verfügbar? / Dokumentlieferung
doi:10.22028/D291-39833
Titel: | Intravenous thrombolysis with tPA and cortical involvement increase the risk of early poststroke seizures: Results of a case-control study |
VerfasserIn: | Brigo, Francesco Schneider, Maximilian Wagenpfeil, Gudrun Ragoschke-Schumm, Andreas Fousse, Mathias Holzhoffer, Claudia Nardone, Raffaele Faßbender, Klaus Lochner, Piergiorgio |
Sprache: | Englisch |
Titel: | Epilepsy & behavior |
Bandnummer: | 104 |
Heft: | Pt B |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2020 |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | The aim of this study was to identify the risk factors for early poststroke seizures (PSS) in patients with acute ischemic stroke. We undertook a case-control study at a single stroke center. Patients with seizure occurring during the first 7 days following ischemic stroke admitted between 2010 and 2016 were retrospectively identified and matched with controls (patients with stroke without early PSS) for age and sex. We included 79 cases and 158 controls. Blood sugar levels on admission, stroke localization, National Institutes of Health Stroke Scale (NIHSS) and Rankin score, and intravenous (i.v.) thrombolysis with recombinant tissue plasminogen activator (rtPA) were statistically associated with early PSS in univariate analysis. Multiple logistic regression after forward and backward variable selection identified cortical stroke localization (odds ratio (OR): 2.49; 95% confidence intervals (CI): 1.35 to 4.59; p = 0.003) and i.v. thrombolysis (OR: 2.26; 95% CI: 1.16 to 4.43; p = 0.008) as variables independently associated with early PSS. Cortical involvement and i.v. thrombolysis are independent risk factors associated with the occurrence of early PSS. This association is not explained by age or sex, concomitant drugs, diabetes or alcoholism, sodium and cholesterol levels, blood pressure on admission, stroke etiology or severity, and hemorrhage following i.v. thrombolysis. Further studies are required to fully elucidate the association between different reperfusion therapies and early PSS. This article is part of the Special Issue "Seizures & Stroke". |
DOI der Erstveröffentlichung: | 10.1016/j.yebeh.2019.04.056 |
URL der Erstveröffentlichung: | https://www.sciencedirect.com/science/article/abs/pii/S1525505019302501 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-398331 hdl:20.500.11880/35877 http://dx.doi.org/10.22028/D291-39833 |
ISSN: | 15255050 |
Datum des Eintrags: | 23-Mai-2023 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Medizinische Biometrie, Epidemiologie und medizinische Informatik M - Neurologie und Psychiatrie |
Professur: | M - Prof. Dr. Klaus Faßbender |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Es gibt keine Dateien zu dieser Ressource.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt.