Please use this identifier to cite or link to this item: doi:10.22028/D291-39833
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Title: Intravenous thrombolysis with tPA and cortical involvement increase the risk of early poststroke seizures: Results of a case-control study
Author(s): Brigo, Francesco
Schneider, Maximilian
Wagenpfeil, Gudrun
Ragoschke-Schumm, Andreas
Fousse, Mathias
Holzhoffer, Claudia
Nardone, Raffaele
Faßbender, Klaus
Lochner, Piergiorgio
Language: English
Title: Epilepsy & behavior
Volume: 104
Issue: Pt B
Publisher/Platform: Elsevier
Year of Publication: 2020
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: The aim of this study was to identify the risk factors for early poststroke seizures (PSS) in patients with acute ischemic stroke. We undertook a case-control study at a single stroke center. Patients with seizure occurring during the first 7 days following ischemic stroke admitted between 2010 and 2016 were retrospectively identified and matched with controls (patients with stroke without early PSS) for age and sex. We included 79 cases and 158 controls. Blood sugar levels on admission, stroke localization, National Institutes of Health Stroke Scale (NIHSS) and Rankin score, and intravenous (i.v.) thrombolysis with recombinant tissue plasminogen activator (rtPA) were statistically associated with early PSS in univariate analysis. Multiple logistic regression after forward and backward variable selection identified cortical stroke localization (odds ratio (OR): 2.49; 95% confidence intervals (CI): 1.35 to 4.59; p = 0.003) and i.v. thrombolysis (OR: 2.26; 95% CI: 1.16 to 4.43; p = 0.008) as variables independently associated with early PSS. Cortical involvement and i.v. thrombolysis are independent risk factors associated with the occurrence of early PSS. This association is not explained by age or sex, concomitant drugs, diabetes or alcoholism, sodium and cholesterol levels, blood pressure on admission, stroke etiology or severity, and hemorrhage following i.v. thrombolysis. Further studies are required to fully elucidate the association between different reperfusion therapies and early PSS. This article is part of the Special Issue "Seizures & Stroke".
DOI of the first publication: 10.1016/j.yebeh.2019.04.056
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-398331
ISSN: 15255050
Date of registration: 23-May-2023
Faculty: M - Medizinische Fakultät
Department: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
M - Neurologie und Psychiatrie
Professorship: M - Prof. Dr. Klaus Faßbender
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