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doi:10.22028/D291-39830
Title: | Association of Vitamin D Receptor Gene Polymorphisms With Melanoma Risk: A Meta-analysis and Systematic Review |
Author(s): | Birke, Michelle Schöpe, Jakob Wagenpfeil, Stefan Vogt, Thomas Reichrath, Jörg |
Language: | English |
Title: | Anticancer research |
Volume: | 40 |
Issue: | 2 |
Pages: | 583-595 |
Publisher/Platform: | Stanford University Highwire Press, International Institute of Anticancer Research |
Year of Publication: | 2020 |
Free key words: | Gene polymorphism malignant melanoma melanoma risk meta-analysis vitamin D receptor review |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Background/Aim: Increasing evidence indicates a relevance of the vitamin D endocrine system for pathogenesis of malignant melanoma. We performed a systematic review and meta-analysis to update previous reports that investigated the association between vitamin D receptor (VDR) gene polymorphisms and melanoma risk. Materials and Methods: A comprehensive literature search (PubMed, ISI Web of Science) identified a total of 14 studies that were eligible for inclusion in our meta-analysis. In the statistical analysis, the ORs and the 95% CIs were calculated for the dominant and recessive models for seven VDR gene polymorphisms, namely rs2228570 (FokI), rs731236 (TaqI), rs1544410 (BsmI), rs4516035 (A-1012G), rs11568820 (Cdx2), rs7975232 (ApaI) and rs739837 (BglI). Results were illustrated in Forest Plots. Publication bias was tested using Funnel Plots and the Egger's test. Results: Our meta-analysis showed in the dominant model (Bb + BB vs. bb) a significant association of a 15% risk reduction in malignant melanoma incidence for carriers of the rarer allele B of rs1544410 (Bsml). Notably, the dominant model (Ff + ff vs. FF) of rs2228570 (FokI) demonstrates that carriers of the rarer allele f are 22% more likely to develop malignant melanoma. For rs7975232 (ApaI), there is a 20% higher risk of melanoma for carriers of the rarer a allele (Aa + aa vs. AA). The results of the meta-analysis revealed no significant association between melanoma risk and the other investigated VDR polymorphisms. Conclusion: The VDR variants FokI, ApaI and BsmI may influence the susceptibility to developing melanoma. These findings support the concept, that the vitamin D endocrine system is of importance for pathogenesis of malignant melanoma. |
DOI of the first publication: | 10.21873/anticanres.13988 |
URL of the first publication: | https://ar.iiarjournals.org/content/40/2/583 |
Link to this record: | urn:nbn:de:bsz:291--ds-398305 hdl:20.500.11880/35876 http://dx.doi.org/10.22028/D291-39830 |
ISSN: | 0250-7005 1791-7530 |
Date of registration: | 23-May-2023 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Dermatologie M - Medizinische Biometrie, Epidemiologie und medizinische Informatik |
Professorship: | M - Prof. Dr. Thomas Vogt M - Prof. Dr. Stefan Wagenpfeil |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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