Please use this identifier to cite or link to this item: doi:10.22028/D291-39820
Title: Revealing the Meissner Corpuscles in Human Glabrous Skin Using In Vivo Non-Invasive Imaging Techniques
Author(s): Infante, Victor Hugo Pacagnelli
Bennewitz, Roland
Klein, Anna Lena
Meinke, Martina C.
Language: English
Title: International Journal of Molecular Sciences
Volume: 24
Issue: 8
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: Meissner corpuscles
glabrous skin
laser scan microscopy
optical coherence tomography
tactile perception
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: The presence of mechanoreceptors in glabrous skin allows humans to discriminate textures by touch. The amount and distribution of these receptors defines our tactile sensitivity and can be affected by diseases such as diabetes, HIV-related pathologies, and hereditary neuropathies. The quantification of mechanoreceptors as clinical markers by biopsy is an invasive method of diagnosis. We report the localization and quantification of Meissner corpuscles in glabrous skin using in vivo, non-invasive optical microscopy techniques. Our approach is supported by the discovery of epidermal protrusions which are co-localized with Meissner corpuscles. Index fingers, small fingers, and tenar palm regions of ten participants were imaged by optical coherence tomography (OCT) and laser scan microscopy (LSM) to determine the thickness of the stratum corneum and epidermis and to count the Meissner corpuscles. We discovered that regions containing Meissner corpuscles could be easily identified by LSM with an enhanced optical reflectance above the corpuscles, caused by a protrusion of the strongly reflecting epidermis into the stratum corneum with its weak reflectance. We suggest that this local morphology above Meissner corpuscles has a function in tactile perception.
DOI of the first publication: 10.3390/ijms24087121
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-398206
ISSN: 1422-0067
Date of registration: 23-May-2023
Description of the related object: Supplementary Materials
Related object:
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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