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doi:10.22028/D291-39809 | Title: | Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality |
| Author(s): | Schunk, Stefan J Kleber, Marcus E März, Winfried Pang, Shichao Zewinger, Stephen Triem, Sarah Ege, Philipp Reichert, Matthias C Krawczyk, Marcin Weber, Susanne N Jaumann, Isabella Schmit, David Sarakpi, Tamim Wagenpfeil, Stefan Kramann, Rafael Boerwinkle, Eric Ballantyne, Christie M Grove, Megan L Tragante, Vinicius Pilbrow, Anna P Richards, A Mark Cameron, Vicky A Doughty, Robert N Dubé, Marie-Pierre Tardif, Jean-Claude Feroz-Zada, Yassamin Sun, Maxine Liu, Chang Ko, Yi-An Quyyumi, Arshed A Hartiala, Jaana A Tang, W H Wilson Hazen, Stanley L Allayee, Hooman McDonough, Caitrin W Gong, Yan Cooper-DeHoff, Rhonda M Johnson, Julie A Scholz, Markus Teren, Andrej Burkhardt, Ralph Martinsson, Andreas Smith, J Gustav Wallentin, Lars James, Stefan K Eriksson, Niclas White, Harvey Held, Claes Waterworth, Dawn Trompet, Stella Jukema, J Wouter Ford, Ian Stott, David J Sattar, Naveed Cresci, Sharon Spertus, John A Campbell, Hannah Tierling, Sascha Walter, Jörn Ampofo, Emmanuel Niemeyer, Barbara A Lipp, Peter Schunkert, Heribert Böhm, Michael Koenig, Wolfgang Fliser, Danilo Laufs, Ulrich Speer, Thimoteus |
| Language: | English |
| Title: | European heart journal |
| Volume: | 42 |
| Issue: | 18 |
| Pages: | 1742–1756 |
| Publisher/Platform: | Oxford University Press |
| Year of Publication: | 2021 |
| Free key words: | Cardiovascular diseases Coronary artery disease Inflammation Inflammasome NLRP3 |
| DDC notations: | 570 Life sciences, biology 610 Medicine and health |
| Publikation type: | Journal Article |
| Abstract: | Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality in humans are unknown. |
| DOI of the first publication: | 10.1093/eurheartj/ehab107 |
| URL of the first publication: | https://doi.org/10.1093/eurheartj/ehab107 |
| Link to this record: | urn:nbn:de:bsz:291--ds-398099 hdl:20.500.11880/35863 http://dx.doi.org/10.22028/D291-39809 |
| ISSN: | 0195-668X 1522-9645 |
| Date of registration: | 22-May-2023 |
| Faculty: | M - Medizinische Fakultät NT - Naturwissenschaftlich- Technische Fakultät |
| Department: | M - Chirurgie M - Medizinische Biometrie, Epidemiologie und medizinische Informatik NT - Biowissenschaften |
| Professorship: | M - Prof. Dr. Michael D. Menger M - Prof. Dr. Stefan Wagenpfeil NT - Prof. Dr. Jörn Walter |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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