Please use this identifier to cite or link to this item: doi:10.22028/D291-39809
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Title: Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality
Author(s): Schunk, Stefan J
Kleber, Marcus E
März, Winfried
Pang, Shichao
Zewinger, Stephen
Triem, Sarah
Ege, Philipp
Reichert, Matthias C
Krawczyk, Marcin
Weber, Susanne N
Jaumann, Isabella
Schmit, David
Sarakpi, Tamim
Wagenpfeil, Stefan
Kramann, Rafael
Boerwinkle, Eric
Ballantyne, Christie M
Grove, Megan L
Tragante, Vinicius
Pilbrow, Anna P
Richards, A Mark
Cameron, Vicky A
Doughty, Robert N
Dubé, Marie-Pierre
Tardif, Jean-Claude
Feroz-Zada, Yassamin
Sun, Maxine
Liu, Chang
Ko, Yi-An
Quyyumi, Arshed A
Hartiala, Jaana A
Tang, W H Wilson
Hazen, Stanley L
Allayee, Hooman
McDonough, Caitrin W
Gong, Yan
Cooper-DeHoff, Rhonda M
Johnson, Julie A
Scholz, Markus
Teren, Andrej
Burkhardt, Ralph
Martinsson, Andreas
Smith, J Gustav
Wallentin, Lars
James, Stefan K
Eriksson, Niclas
White, Harvey
Held, Claes
Waterworth, Dawn
Trompet, Stella
Jukema, J Wouter
Ford, Ian
Stott, David J
Sattar, Naveed
Cresci, Sharon
Spertus, John A
Campbell, Hannah
Tierling, Sascha
Walter, Jörn
Ampofo, Emmanuel
Niemeyer, Barbara A
Lipp, Peter
Schunkert, Heribert
Böhm, Michael
Koenig, Wolfgang
Fliser, Danilo
Laufs, Ulrich
Speer, Thimoteus
Language: English
Title: European heart journal
Volume: 42
Issue: 18
Pages: 1742–1756
Publisher/Platform: Oxford University Press
Year of Publication: 2021
Free key words: Cardiovascular diseases
Coronary artery disease
DDC notations: 570 Life sciences, biology
610 Medicine and health
Publikation type: Journal Article
Abstract: Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality in humans are unknown.
DOI of the first publication: 10.1093/eurheartj/ehab107
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-398099
ISSN: 0195-668X
Date of registration: 22-May-2023
Faculty: M - Medizinische Fakultät
NT - Naturwissenschaftlich- Technische Fakultät
Department: M - Chirurgie
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
NT - Biowissenschaften
Professorship: M - Prof. Dr. Michael D. Menger
M - Prof. Dr. Stefan Wagenpfeil
NT - Prof. Dr. Jörn Walter
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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