Please use this identifier to cite or link to this item: doi:10.22028/D291-38919
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Title: Flowing droplet interface bilayers: A microfluidic tool to control droplet trajectories and to study mechanical properties of unsupported lipid bilayers
Author(s): Walter, Cornelia
Seemann, Ralf
Fleury, Jean-Baptiste
Language: English
Title: Biomicrofluidics
Volume: 14
Issue: 4
Publisher/Platform: AIP Publishing
Year of Publication: 2020
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: We introduce the concept of Flowing Droplet Interface Bilayers (FDIBs) that are made of two droplets maintained in contact due to the presence of an adhesive lipidic surfactant. This system is similar to a flowing dumbbell made of two droplets interconnected by a lipid bilayer and driven by an external flow. Interestingly, such a dumbbell does not show a straight flow trajectory, but it oscillates between the sidewalls while moving along the microchannel. The origin of this unusual motion is hydrodynamic interactions, as demonstrated by analytical calculations and micro particle image velocimentry (μPiV) measurements. The hydrodynamic motion appears to be highly sensitive to the mechanical properties of the lipid bilayer connecting the two droplets (FDIB). Thus, droplet trajectories can be controlled by tuning the lipid bilayer composition, which enables in turn investigating mechanical properties of free-standing lipid bilayers.
DOI of the first publication: 10.1063/5.0011489
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-389195
ISSN: 1932-1058
Date of registration: 6-Feb-2023
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Ralf Seemann
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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