Please use this identifier to cite or link to this item: doi:10.22028/D291-38679
Title: Epidemiology and Characteristics of Gastric Carcinoma in Childhood : An Analysis of Data from Population-Based and Clinical Cancer Registries
Author(s): Abele, Michael
Grabner, Lisa
Blessing, Tabea
Block, Andreas
Agaimy, Abbas
Kratz, Christian
Simon, Thorsten
Calaminus, Gabriele
Heine, Sabine
Corbacioglu, Selim
Christiansen, Holger
Schneider, Dominik T.
Brecht, Ines B.
Language: English
Title: Cancers
Volume: 15
Issue: 1
Publisher/Platform: MDPI
Year of Publication: 2023
Free key words: gastric cancer
rare tumors
pediatric oncology
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: (1) Background: Gastric carcinoma is an exceptionally rare tumor in childhood. Little is known about the etiology, epidemiology, and clinical features of pediatric gastric carcinomas. This analysis aimed to fill this gap by increasing knowledge about the occurrence of gastric carcinoma in childhood. (2) Material and methods: Data from gastric carcinoma cases diagnosed between 2000 and 2017/2018 were retrieved from the Surveillance, Epidemiology, and End Results Program (SEER) and the German Center for Cancer Registry Data. Data from patients <20 years of age were analyzed for patient- and tumor-related characteristics. In addition, clinical data from patients with gastric carcinoma registered in the German Registry for Rare Pediatric Tumors (STEP) were analyzed for diagnostics, therapy, and outcome. (3) Results: Ninety-one cases of gastric carcinoma, mainly in adolescents, were identified in the epidemiologic cancer registries. Among patients with recorded staging data, advanced tumor stages were common (66.7%). Within the follow-up period covered, 63.7% of patients with clinical follow-up data died. Eight pediatric patients with gastric carcinoma were enrolled in the STEP registry, among whom two were patients with hereditary CDH1 mutations and another was a patient with Peutz–Jeghers syndrome. Three patients were found to have distinctly decreased immunoglobulin concentrations. All four patients in whom complete resection was achieved remained in remission. Three of the other four patients died despite multimodal therapy. (4) Conclusions: A combination of Helicobacter pylori infection and tumor predisposition and/or immunodeficiency appears to promote the development of gastric carcinoma in childhood. While patients with localized disease stages have a good chance of achieving durable remission through complete resection, patients with stage IV carcinomas face a dismal prognosis, highlighting the need to develop new strategies such as mutation-guided treatments.
DOI of the first publication: 10.3390/cancers15010317
Link to this record: urn:nbn:de:bsz:291--ds-386799
ISSN: 2072-6694
Date of registration: 16-Jan-2023
Description of the related object: Supplementary Materials
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Pädiatrie
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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