Please use this identifier to cite or link to this item: doi:10.22028/D291-38321
Title: Effects of cardiovascular single pill combinations compared with identical multi-pill therapies on healthcare cost and utilization in Germany
Author(s): Wilke, Thomas
Weisser, Burkhard
Predel, Hans-Georg
Schmieder, Roland E.
Wassmann, Sven
Gillessen, Anton
Blettenberg, Jörg
Maywald, Ulf
Randerath, Olaf
Müller, Sabrina
Böhm, Michael
Language: English
Title: Journal of Comparative Effectiveness Research
Volume: 11
Issue: 6
Pages: 411–422
Publisher/Platform: Future Medicine
Year of Publication: 2022
Free key words: cardiology/cardiovascular
comparative effectiveness research
real-world evidence
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Aim: This study assessed whether a single pill combination (SPC) is associated with lower direct healthcare costs. Materials & methods: Anonymized claims data of patients ≥18 years treated with drugs for cardiovascular (CV)-related diseases either as a single pill combination or multi-pill combination (followup to 1 year) were evaluated. After propensity score matching, 59,336 out of 1,369,840 patients were analyzed. Results: In all cohorts, patients receiving a single pill combination had a lower frequency of general practitioner and specialist visits. The patients also had a significantly lower ratio of all-cause hospitalization days and number of CV-related prescriptions as well as all-cause prescriptions (with one exception) compared with those receiving a multi-pill combination. Conclusion: Direct CV-related costs were significantly lower in four out of seven comparisons, with a trend toward lower costs in the other three comparisons.
DOI of the first publication: 10.2217/cer-2021-0197
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-383215
ISSN: 2042-6313
Date of registration: 30-Nov-2022
Description of the related object: Supplementary data
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Michael Böhm
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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