Please use this identifier to cite or link to this item:
doi:10.22028/D291-38320
Title: | Enhanced intraperitoneal delivery of charged, aerosolized curcumin nanoparticles by electrostatic precipitation |
Author(s): | Castagna, Arianna Zander, Alexandra J. Sautkin, Iaroslaw Schneider, Marc Shegokar, Ranjita Königsrainer, Alfred Reymond, Marc André |
Language: | English |
Title: | Nanomedicine |
Volume: | 16 |
Issue: | 2 |
Pages: | 109–120 |
Publisher/Platform: | Future Medicine |
Year of Publication: | 2021 |
Free key words: | curcumin electromotive drug administration electrostatic precipitation intraperitoneal drug delivery nanoparticles PIPAC polylactic-co-glycolic acid (PLGA) zeta potential |
DDC notations: | 500 Science |
Publikation type: | Journal Article |
Abstract: | Aims: To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Methods: Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders ex vivo. The experiment was repeated with the additional use of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (electrostatic PIPAC). Results: Positively charged CUR-PLGA-NPs increased depth of tissue penetration by 81.5% and tissue concentration by 80%. Electrostatic precipitation further improved the uptake of positively charged CUR-PLGA-NPs by 41.8%. Conclusion: The combination of positive charge and electrostatic precipitation have significant potential to improve tissue uptake of nanoparticles during intraperitoneal chemotherapy. |
DOI of the first publication: | 10.2217/nnm-2020-0373 |
URL of the first publication: | http://dx.doi.org/10.2217/nnm-2020-0373 |
Link to this record: | urn:nbn:de:bsz:291--ds-383201 hdl:20.500.11880/34578 http://dx.doi.org/10.22028/D291-38320 |
ISSN: | 1748-6963 1743-5889 |
Date of registration: | 30-Nov-2022 |
Description of the related object: | Supplementary data |
Related object: | https://www.futuremedicine.com/doi/suppl/10.2217/nnm-2020-0373/suppl_file/supplementary+figure+1.jpg |
Faculty: | NT - Naturwissenschaftlich- Technische Fakultät |
Department: | NT - Pharmazie |
Professorship: | NT - Prof. Dr. Marc Schneider |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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File | Description | Size | Format | |
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nnm-2020-0373.pdf | 5,42 MB | Adobe PDF | View/Open |
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