Please use this identifier to cite or link to this item: doi:10.22028/D291-38320
Title: Enhanced intraperitoneal delivery of charged, aerosolized curcumin nanoparticles by electrostatic precipitation
Author(s): Castagna, Arianna
Zander, Alexandra J.
Sautkin, Iaroslaw
Schneider, Marc
Shegokar, Ranjita
Königsrainer, Alfred
Reymond, Marc André
Language: English
Title: Nanomedicine
Volume: 16
Issue: 2
Pages: 109–120
Publisher/Platform: Future Medicine
Year of Publication: 2021
Free key words: curcumin
electromotive drug administration
electrostatic precipitation
intraperitoneal drug delivery
polylactic-co-glycolic acid (PLGA)
zeta potential
DDC notations: 500 Science
Publikation type: Journal Article
Abstract: Aims: To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Methods: Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders ex vivo. The experiment was repeated with the additional use of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (electrostatic PIPAC). Results: Positively charged CUR-PLGA-NPs increased depth of tissue penetration by 81.5% and tissue concentration by 80%. Electrostatic precipitation further improved the uptake of positively charged CUR-PLGA-NPs by 41.8%. Conclusion: The combination of positive charge and electrostatic precipitation have significant potential to improve tissue uptake of nanoparticles during intraperitoneal chemotherapy.
DOI of the first publication: 10.2217/nnm-2020-0373
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-383201
ISSN: 1748-6963
Date of registration: 30-Nov-2022
Description of the related object: Supplementary data
Related object:
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Marc Schneider
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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