Please use this identifier to cite or link to this item:
doi:10.22028/D291-38313
Title: | Concepts and clinical aspects of active implants for the treatment of bone fractures |
Author(s): | Ganse, Bergita Orth, Marcel Roland, Michael Diebels, Stefan Motzki, Paul Seelecke, Stefan Kirsch, Susanne-Marie Welsch, Felix Andres, Annchristin Wickert, Kerstin Braun, Benedikt J. Pohlemann, Tim |
Language: | English |
Title: | Acta Biomaterialia |
Volume: | 146 |
Pages: | 1-9 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2022 |
Free key words: | Fracture healing Surgery Trauma Smart implant Shape memory alloy |
DDC notations: | 500 Science 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Nonunion is a complication of long bone fractures that leads to disability, morbidity and high costs. Early detection is difficult and treatment through external stimulation and revision surgery is often a lengthy process. Therefore, alternative diagnostic and therapeutic options are currently being explored, including the use of external and internal sensors. Apart from monitoring fracture stiffness and displacement directly at the fracture site, it would be desirable if an implant could also vary its stiffness and apply an intervention to promote healing, if needed. This could be achieved either by a predetermined protocol, by remote control, or even by processing data and triggering the intervention itself (self-regulated ‘intelligent’ or ‘smart’ implant). So-called active or smart materials like shape memory alloys (SMA) have opened up opportunities to build active implants. For example, implants could stimulate fracture healing by active shortening and lengthening via SMA actuator wires; by emitting pulses, waves, or electromagnetic fields. However, it remains undefined which modes of application, forces, frequencies, force directions, time durations and periods, or other stimuli such implants should ideally deliver for the best result. The present paper reviews the literature on active implants and interventions for nonunion, discusses possible mechanisms of active implants and points out where further research and development are needed to build an active implant that applies the most ideal intervention. |
DOI of the first publication: | 10.1016/j.actbio.2022.05.001 |
URL of the first publication: | http://dx.doi.org/10.1016/j.actbio.2022.05.001 |
Link to this record: | urn:nbn:de:bsz:291--ds-383130 hdl:20.500.11880/34570 http://dx.doi.org/10.22028/D291-38313 |
ISSN: | 1742-7061 |
Date of registration: | 30-Nov-2022 |
Faculty: | M - Medizinische Fakultät NT - Naturwissenschaftlich- Technische Fakultät |
Department: | M - Chirurgie NT - Materialwissenschaft und Werkstofftechnik NT - Systems Engineering |
Professorship: | M - Prof. Dr. med. Bergita Ganse M - Prof. Dr. Tim Pohlemann NT - Prof. Dr. Stefan Diebels |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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1-s2.0-S1742706122002707-main.pdf | 1,74 MB | Adobe PDF | View/Open |
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