Please use this identifier to cite or link to this item: doi:10.22028/D291-38313
Title: Concepts and clinical aspects of active implants for the treatment of bone fractures
Author(s): Ganse, Bergita
Orth, Marcel
Roland, Michael
Diebels, Stefan
Motzki, Paul
Seelecke, Stefan
Kirsch, Susanne-Marie
Welsch, Felix
Andres, Annchristin
Wickert, Kerstin
Braun, Benedikt J.
Pohlemann, Tim
Language: English
Title: Acta Biomaterialia
Volume: 146
Pages: 1-9
Publisher/Platform: Elsevier
Year of Publication: 2022
Free key words: Fracture healing
Smart implant
Shape memory alloy
DDC notations: 500 Science
610 Medicine and health
Publikation type: Journal Article
Abstract: Nonunion is a complication of long bone fractures that leads to disability, morbidity and high costs. Early detection is difficult and treatment through external stimulation and revision surgery is often a lengthy process. Therefore, alternative diagnostic and therapeutic options are currently being explored, including the use of external and internal sensors. Apart from monitoring fracture stiffness and displacement directly at the fracture site, it would be desirable if an implant could also vary its stiffness and apply an intervention to promote healing, if needed. This could be achieved either by a predetermined protocol, by remote control, or even by processing data and triggering the intervention itself (self-regulated ‘intelligent’ or ‘smart’ implant). So-called active or smart materials like shape memory alloys (SMA) have opened up opportunities to build active implants. For example, implants could stimulate fracture healing by active shortening and lengthening via SMA actuator wires; by emitting pulses, waves, or electromagnetic fields. However, it remains undefined which modes of application, forces, frequencies, force directions, time durations and periods, or other stimuli such implants should ideally deliver for the best result. The present paper reviews the literature on active implants and interventions for nonunion, discusses possible mechanisms of active implants and points out where further research and development are needed to build an active implant that applies the most ideal intervention.
DOI of the first publication: 10.1016/j.actbio.2022.05.001
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-383130
ISSN: 1742-7061
Date of registration: 30-Nov-2022
Faculty: M - Medizinische Fakultät
NT - Naturwissenschaftlich- Technische Fakultät
Department: M - Chirurgie
NT - Materialwissenschaft und Werkstofftechnik
NT - Systems Engineering
Professorship: M - Prof. Dr. med. Bergita Ganse
M - Prof. Dr. Tim Pohlemann
NT - Prof. Dr. Stefan Diebels
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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