Please use this identifier to cite or link to this item:
doi:10.22028/D291-37944
Title: | PR3-ANCAs Detected by Third-Generation ELISA Predicts Severe Disease and Poor Survival in Primary Sclerosing Cholangitis |
Author(s): | Lopens, Steffi Wunsch, Ewa Milkiewicz, Malgorzata Röber, Nadja Zarske, Grit Nasser, Abdullah Conrad, Karsten Laass, Martin Rödiger, Stefan Krawczyk, Marcin Roggenbuck, Dirk Milkiewicz, Piotr |
Language: | English |
Title: | Diagnostics |
Volume: | 12 |
Issue: | 11 |
Publisher/Platform: | MDPI |
Year of Publication: | 2022 |
Free key words: | primary sclerosing cholangitis antibodies against serine protease proteinase-3 survival health-related quality of life liver biochemistry disease severity |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | A highly sensitive detection of anti-neutrophil cytoplasmic antibodies to serine proteinase-3 (PR3-ANCAs) aids in the serological diagnosis of autoimmune liver disorders and the prediction of severity in primary sclerosing cholangitis (PSC). Here, we evaluate a novel thirdgeneration ELISA for the detection of PR3-ANCAs. In total, 309 patients with PSC, 51 with primary biliary cholangitis (PBC), and 120 healthy blood donors (BD) were analyzed. For the survival analysis in PSC, the outcome was defined as liver-transplantation-free survival during the followup. Positive PR3-ANCA levels were found in 74/309 (24.0%) of patients with PSC. No BDs and one patient with PBC demonstrated PR3-ANCA positivity. PR3-ANCAs were revealed as independent predictors for a poor PSC outcome (study endpoint: liver transplantation/death, log-rank test, p = 0.02). PR3-ANCA positivity, lower albumin levels, and higher bilirubin concentrations were independent risks of a poor survival (Cox proportional-hazards regression analysis, p < 0.05). The Mayo risk score for PSC was associated with PR3-ANCA positivity (p = 0.01) and the disease severity assessed with a model of end-stage liver disease (MELD) and extended MELD-Na (p < 0.05). PR3-ANCAs detected by a third-generation ELISA are diagnostic and prognostic markers for PSC. Their wider use could help to identify patients who are at-risk of a more severe disease. |
DOI of the first publication: | 10.3390/diagnostics12112682 |
Link to this record: | urn:nbn:de:bsz:291--ds-379449 hdl:20.500.11880/34299 http://dx.doi.org/10.22028/D291-37944 |
ISSN: | 2075-4418 |
Date of registration: | 11-Nov-2022 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Professorship: | M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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File | Description | Size | Format | |
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diagnostics-12-02682.pdf | 530,5 kB | Adobe PDF | View/Open |
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