Please use this identifier to cite or link to this item: doi:10.22028/D291-37944
Title: PR3-ANCAs Detected by Third-Generation ELISA Predicts Severe Disease and Poor Survival in Primary Sclerosing Cholangitis
Author(s): Lopens, Steffi
Wunsch, Ewa
Milkiewicz, Malgorzata
Röber, Nadja
Zarske, Grit
Nasser, Abdullah
Conrad, Karsten
Laass, Martin
Rödiger, Stefan
Krawczyk, Marcin
Roggenbuck, Dirk
Milkiewicz, Piotr
Language: English
Title: Diagnostics
Volume: 12
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2022
Free key words: primary sclerosing cholangitis
antibodies against serine protease proteinase-3
health-related quality of life
liver biochemistry
disease severity
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: A highly sensitive detection of anti-neutrophil cytoplasmic antibodies to serine proteinase-3 (PR3-ANCAs) aids in the serological diagnosis of autoimmune liver disorders and the prediction of severity in primary sclerosing cholangitis (PSC). Here, we evaluate a novel thirdgeneration ELISA for the detection of PR3-ANCAs. In total, 309 patients with PSC, 51 with primary biliary cholangitis (PBC), and 120 healthy blood donors (BD) were analyzed. For the survival analysis in PSC, the outcome was defined as liver-transplantation-free survival during the followup. Positive PR3-ANCA levels were found in 74/309 (24.0%) of patients with PSC. No BDs and one patient with PBC demonstrated PR3-ANCA positivity. PR3-ANCAs were revealed as independent predictors for a poor PSC outcome (study endpoint: liver transplantation/death, log-rank test, p = 0.02). PR3-ANCA positivity, lower albumin levels, and higher bilirubin concentrations were independent risks of a poor survival (Cox proportional-hazards regression analysis, p < 0.05). The Mayo risk score for PSC was associated with PR3-ANCA positivity (p = 0.01) and the disease severity assessed with a model of end-stage liver disease (MELD) and extended MELD-Na (p < 0.05). PR3-ANCAs detected by a third-generation ELISA are diagnostic and prognostic markers for PSC. Their wider use could help to identify patients who are at-risk of a more severe disease.
DOI of the first publication: 10.3390/diagnostics12112682
Link to this record: urn:nbn:de:bsz:291--ds-379449
ISSN: 2075-4418
Date of registration: 11-Nov-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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