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Titel: Management of Germ Cell Tumours of the Testis in Adult Patients. German Clinical Practice Guideline Part I : Epidemiology, Classification, Diagnosis, Prognosis, Fertility Preservation, and Treatment Recommendations for Localized Stages
VerfasserIn: Kliesch, Sabine
Schmidt, Stefanie
Wilborn, Doris
Aigner, Clemens
Albrecht, Walter
Bedke, Jens
Beintker, Matthias
Beyersdorff, Dirk
Bokemeyer, Carsten
Busch, Jonas
Classen, Johannes
de Wit, Maike
Dieckmann, Klaus-Peter
Diemer, Thorsten
Dieing, Anette
Gockel, Matthias
Göckel-Beining, Bernt
Hakenberg, Oliver W.
Heidenreich, Axel
Heinzelbecker, Julia
Herkommer, Kathleen
Hermanns, Thomas
Kaufmann, Sascha
Kornmann, Marko
Kotzerke, Jörg
Krege, Susanne
Kristiansen, Glen
Lorch, Anja
Müller, Arndt-Christian
Oechsle, Karin
Ohloff, Timur
Oing, Christoph
Otto, Ulrich
Pfister, David
Pichler, Renate
Recken, Heinrich
Rick, Oliver
Rudolph, Yvonne
Ruf, Christian
Schirren, Joachim
Schmelz, Hans
Schmidberger, Heinz
Schrader, Mark
Schweyer, Stefan
Seeling, Stefanie
Souchon, Rainer
Winter, Christian
Wittekind, Christian
Zengerling, Friedemann
Zermann, Dirk-Henrik
Zillmann, Roger
Albers, Peter
Sprache: Englisch
Titel: Urologia Internationalis
Bandnummer: 105
Heft: 3-4
Seiten: 169–180
Verlag/Plattform: Karger
Erscheinungsjahr: 2021
Freie Schlagwörter: Germ cell tumour of the testis
Diagnosis
Prognosis
Staging
Fertility preservation
Clinical practice guideline
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Introduction: This is the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up on germ cell tumours (GCTs) of the testis in adult patients. We present the guideline content in two publications. Part I covers the topic’s background, methods, epidemiology, classification systems, diagnostics, prognosis, and treatment recommendations for the localized stages. Methods: An interdisciplinary panel of 42 experts including 1 patient representative developed the guideline content. Clinical recommendations and statements were based on scientific evidence and expert consensus. For this purpose, evidence tables for several review questions, which were based on systematic literature searches (last search was in March 2018) were provided. Thirty-one experts entitled to vote, rated the final clinical recommendations and statements. Results: We provide 161 clinical recommendations and statements. We present information on the quality of cancer care and epidemiology and give recommendations for staging and classification as well as for diagnostic procedures. The diagnostic recommendations encompass measures for assessing the primary tumour as well as procedures for the detection of metastases. One chapter addresses prognostic factors. In part I, we separately present the treatment recommendations for germ cell neoplasia in situ, and the organ-confined stages (clinical stage I) of both seminoma and nonseminoma. Conclusion: Although GCT is a rare tumour entity with excellent survival rates for the localized stages, its management requires an interdisciplinary approach, including several clinical experts. Quality of care is highly related to institutional expertise and can be reassured by established online-based second-opinion boards. There are very few studies on diagnostics with good level of evidence. Treatment of metastatic GCTs must be tailored to the risk according to the International Germ Cell Cancer Collaboration Group classification after careful diagnostic evaluation. An interdisciplinary approach as well as the referral of selected patients to centres with proven experience can help achieve favourable clinical outcomes.
DOI der Erstveröffentlichung: 10.1159/000510407
URL der Erstveröffentlichung: https://www.karger.com/Article/FullText/510407
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-379114
hdl:20.500.11880/34277
http://dx.doi.org/10.22028/D291-37911
ISSN: 1423-0399
0042-1138
Datum des Eintrags: 9-Nov-2022
Bezeichnung des in Beziehung stehenden Objekts: Supplementary Material
In Beziehung stehendes Objekt: https://karger.figshare.com/ndownloader/files/25980572
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Urologie und Kinderurologie
Professur: M - Prof. Dr. Michael Stöckle
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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