Please use this identifier to cite or link to this item: doi:10.22028/D291-37911
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Title: Management of Germ Cell Tumours of the Testis in Adult Patients. German Clinical Practice Guideline Part I : Epidemiology, Classification, Diagnosis, Prognosis, Fertility Preservation, and Treatment Recommendations for Localized Stages
Author(s): Kliesch, Sabine
Schmidt, Stefanie
Wilborn, Doris
Aigner, Clemens
Albrecht, Walter
Bedke, Jens
Beintker, Matthias
Beyersdorff, Dirk
Bokemeyer, Carsten
Busch, Jonas
Classen, Johannes
de Wit, Maike
Dieckmann, Klaus-Peter
Diemer, Thorsten
Dieing, Anette
Gockel, Matthias
Göckel-Beining, Bernt
Hakenberg, Oliver W.
Heidenreich, Axel
Heinzelbecker, Julia
Herkommer, Kathleen
Hermanns, Thomas
Kaufmann, Sascha
Kornmann, Marko
Kotzerke, Jörg
Krege, Susanne
Kristiansen, Glen
Lorch, Anja
Müller, Arndt-Christian
Oechsle, Karin
Ohloff, Timur
Oing, Christoph
Otto, Ulrich
Pfister, David
Pichler, Renate
Recken, Heinrich
Rick, Oliver
Rudolph, Yvonne
Ruf, Christian
Schirren, Joachim
Schmelz, Hans
Schmidberger, Heinz
Schrader, Mark
Schweyer, Stefan
Seeling, Stefanie
Souchon, Rainer
Winter, Christian
Wittekind, Christian
Zengerling, Friedemann
Zermann, Dirk-Henrik
Zillmann, Roger
Albers, Peter
Language: English
Title: Urologia Internationalis
Volume: 105
Issue: 3-4
Pages: 169–180
Publisher/Platform: Karger
Year of Publication: 2021
Free key words: Germ cell tumour of the testis
Fertility preservation
Clinical practice guideline
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Introduction: This is the first German evidence- and consensus-based clinical guideline on diagnosis, treatment, and follow-up on germ cell tumours (GCTs) of the testis in adult patients. We present the guideline content in two publications. Part I covers the topic’s background, methods, epidemiology, classification systems, diagnostics, prognosis, and treatment recommendations for the localized stages. Methods: An interdisciplinary panel of 42 experts including 1 patient representative developed the guideline content. Clinical recommendations and statements were based on scientific evidence and expert consensus. For this purpose, evidence tables for several review questions, which were based on systematic literature searches (last search was in March 2018) were provided. Thirty-one experts entitled to vote, rated the final clinical recommendations and statements. Results: We provide 161 clinical recommendations and statements. We present information on the quality of cancer care and epidemiology and give recommendations for staging and classification as well as for diagnostic procedures. The diagnostic recommendations encompass measures for assessing the primary tumour as well as procedures for the detection of metastases. One chapter addresses prognostic factors. In part I, we separately present the treatment recommendations for germ cell neoplasia in situ, and the organ-confined stages (clinical stage I) of both seminoma and nonseminoma. Conclusion: Although GCT is a rare tumour entity with excellent survival rates for the localized stages, its management requires an interdisciplinary approach, including several clinical experts. Quality of care is highly related to institutional expertise and can be reassured by established online-based second-opinion boards. There are very few studies on diagnostics with good level of evidence. Treatment of metastatic GCTs must be tailored to the risk according to the International Germ Cell Cancer Collaboration Group classification after careful diagnostic evaluation. An interdisciplinary approach as well as the referral of selected patients to centres with proven experience can help achieve favourable clinical outcomes.
DOI of the first publication: 10.1159/000510407
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-379114
ISSN: 1423-0399
Date of registration: 9-Nov-2022
Description of the related object: Supplementary Material
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Urologie und Kinderurologie
Professorship: M - Prof. Dr. Michael Stöckle
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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