Please use this identifier to cite or link to this item:
doi:10.22028/D291-37798
Title: | Urinary extracellular vesicles : A position paper by the Urine Task Force of the International Society for Extracellular Vesicles |
Author(s): | Erdbrügger, Uta Blijdorp, Charles J. Bijnsdorp, Irene V. Borràs, Francesc E. Burger, Dylan Bussolati, Benedetta Byrd, James Brian Clayton, Aled Dear, James W. Falcón-Pérez, Juan M. Grange, Cristina Hill, Andrew F. Holthöfer, Harry Hoorn, Ewout J. Jenster, Guido Jimenez, Connie R. Junker, Kerstin Klein, John Knepper, Mark A. Koritzinsky, Erik H. Luther, James M. Lenassi, Metka Leivo, Janne Mertens, Inge Musante, Luca Oeyen, Eline Puhka, Maija van Royen, Martin E. Sánchez, Catherine Soekmadji, Carolina Thongboonkerd, Visith van Steijn, Volkert Verhaegh, Gerald Webber, Jason P. Witwer, Kenneth Yuen, Peter S.T. Zheng, Lei Llorente, Alicia Martens-Uzunova, Elena S. |
Language: | English |
Title: | Journal of Extracellular Vesicles |
Volume: | 10 |
Issue: | 7 |
Publisher/Platform: | Wiley |
Year of Publication: | 2021 |
Free key words: | biobank biomarkers bladder extracellular vesicles kidney liquid biopsy prostate rigor and standardization urine |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Urine is commonly used for clinical diagnosis and biomedical research. The discovery of extracellular vesicles (EV) in urine opened a new fast-growing scientific field. In the last decade urinary extracellular vesicles (uEVs) were shown to mirror molecular processes as well as physiological and pathological conditions in kidney, urothelial and prostate tissue. Therefore, several methods to isolate and characterize uEVs have been developed. However, methodological aspects of EV separation and analysis, including normalization of results, need further optimization and standardization to foster scientific advances in uEV research and a subsequent successful translation into clinical practice. This position paper is written by the Urine Task Force of the Rigor and Standardization Subcommittee of ISEV consisting of nephrologists, urologists, cardiologists and biologists with active experience in uEV research. Our aim is to present the state of the art and identify challenges and gaps in current uEV-based analyses for clinical applications. Finally, recommendations for improved rigor, reproducibility and interoperability in uEV research are provided in order to facilitate advances in the field. |
DOI of the first publication: | 10.1002/jev2.12093 |
URL of the first publication: | https://onlinelibrary.wiley.com/doi/10.1002/jev2.12093 |
Link to this record: | urn:nbn:de:bsz:291--ds-377987 hdl:20.500.11880/34184 http://dx.doi.org/10.22028/D291-37798 |
ISSN: | 2001-3078 |
Date of registration: | 3-Nov-2022 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Urologie und Kinderurologie |
Professorship: | M - Prof. Dr. Michael Stöckle |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
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J of Extracellular Vesicle - 2021 - Erdbr gger - Urinary extracellular vesicles A position paper by the Urine Task Force.pdf | 2,76 MB | Adobe PDF | View/Open |
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