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doi:10.22028/D291-37701
Titel: | The prognostic impact of Claudin 6 in papillary renal cell carcinoma |
VerfasserIn: | Mikuteit, Marie Zschäbitz, Stefanie Stöhr, Christine Herrmann, Edwin Polifka, Iris Agaimy, Abbas Trojan, Lutz Ströbel, Philipp Becker, Frank Wülfing, Christian Barth, Peter Stöckle, Michael Staehler, Michael Stief, Christian Haferkamp, Axel Hohenfellner, Markus Macher-Göppinger, Stephan Wullich, Bernd Noldus, Joachim Brenner, Walburgis Roos, Frederik C. Walter, Bernhard Otto, Wolfgang Burger, Maximilian Schrader, Andres Jan Hartmann, Arndt Steffens, Sandra Erlmeier, Franziska |
Sprache: | Englisch |
Titel: | Pathology - Research and Practice |
Bandnummer: | 231 |
Verlag/Plattform: | Elsevier |
Erscheinungsjahr: | 2022 |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background Claudins are promising biomarkers for diagnosis and prognosis or targets for treatment. They play a major role in signal transduction and are important in nearly all aspects of tumorigenesis. Claudin 6 is a member of the claudin family and is part of the tight junction molecule. It is reactivated in several cancer types and serves as prognostic marker in, for example, gastric, breast or non small cell lung cancer. The prognostic role of Claudin 6 in renal cell carcinoma (RCC), especially in papillary RCC (pRCC), is still unclear. Patients and Methods The patients’ sample collection was a joint collaboration of the PANZAR consortium. Patients’ medical history and tumor specimens were collected from n = 240 and n = 128 patients with type 1 and 2 pRCC, respectively. Expression of Claudin 6 was determined by immunohistochemistry. Results In total, Claudin 6 staining was positive in 55 of 240 type 1 and 30 of 128 type 2 pRCC cases. Kaplan-Meier analysis disclosed an overall survival of 84% for Claudin 6- compared to 78% for Claudin 6 + in pRCC type 1 tumors (p = 0.449, log-rank) and 68% for Claudin 6- compared to 65.4% for Claudin 6 + in pRCC type 2 tumors (p = 0.364, log-rank). Conclusion In this study, claudin 6 expression showed no significant association regarding overall survival (OS) and therefore did not qualify as a prognostic marker in pRCC. Future studies will have to determine, whether Claudin 6 plays a prognostic role in other RCC entities. In addition, the function of Claudin 6 as a predictive marker for therapeutic approaches has to be evaluated in future studies. |
DOI der Erstveröffentlichung: | 10.1016/j.prp.2022.153802 |
URL der Erstveröffentlichung: | https://www.sciencedirect.com/science/article/abs/pii/S0344033822000450 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-377018 hdl:20.500.11880/34104 http://dx.doi.org/10.22028/D291-37701 |
ISSN: | 0344-0338 |
Datum des Eintrags: | 25-Okt-2022 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Urologie und Kinderurologie |
Professur: | M - Prof. Dr. Michael Stöckle |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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