Please use this identifier to cite or link to this item:
doi:10.22028/D291-37555
Title: | A lack of a definite correlation between male sub-fertility and single nucleotide polymorphisms in sperm mitochondrial genes MT-CO3, MT-ATP6 and MT-ATP8 |
Author(s): | Saleh Jaweesh, Mayyas Hammadeh, Mohamad Eid Dahadhah, Fatina W. Al Smadi, Mohammad A. Al Zoubi, Mazhar Salim Alarjah, Manal Issam Abu Amor, Houda |
Language: | English |
Title: | Molecular Biology Reports |
Publisher/Platform: | Springer Nature |
Year of Publication: | 2022 |
Free key words: | Male sub-fertility CO3 ATP6 and ATP8 |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Background An inability of a man to conceive a potentially fertile woman after a year of unprotected intercourse is defned as male infertility. It is reported that 30–40% of males in their reproductive years have abnormalities in sperm production, either qualitatively or quantitatively, or both. However, genetic factors result in up to 15% of male infertility cases. The present study aimed to analyze the possible correlations between sub-fertility and polymorphisms in sperm mitochondrial CO3, ATP6 and ATP8 genes in sub-fertile men. Methods and results For 67 sub-fertile and 44 fertile male samples, Sanger sequencing of selected mitochondrial DNA genes was done. A total of twelve SNPs in the MT-CO3 gene: rs2248727, rs7520428, rs3134801, rs9743, rs28358272, rs2853824, rs2856985, rs2854139, rs41347846, rs28380140, rs3902407, and 28,411,821, fourteen SNPs in the MT-ATP6: rs2001031, rs2000975, rs2298011, rs7520428, rs9645429, rs112660509, rs6650105, rs6594033, rs6594034, rs6594035, rs3020563, rs28358887, rs2096044, and rs9283154, and ten SNPs in the MT-ATP8: rs9285835, rs9285836, rs9283154, rs8179289, rs121434446, rs1116906, rs2153588, rs1116905, rs1116907, and rs3020563 were detected in the case and control groups at diferent nucleotide positions. Only the rs7520428 in the MT-CO3 and MT-ATP6 showed a statistically signifcant diference between sub-fertile and fertile groups in the genotype’s and allele’s frequency test (P<0.0001 for both). Conclusion The results of our study suggest that male sub-fertility is linked with rs7520428 SNP in MT-CO3 and MT-ATP6. The studied polymorphic variations in the MT-ATP8 gene, on the contrary, did not reveal any signifcant association with male sub-fertility. |
DOI of the first publication: | 10.1007/s11033-022-07884-2 |
URL of the first publication: | https://link.springer.com/article/10.1007/s11033-022-07884-2 |
Link to this record: | urn:nbn:de:bsz:291--ds-375553 hdl:20.500.11880/33977 http://dx.doi.org/10.22028/D291-37555 |
ISSN: | 1573-4978 0301-4851 |
Date of registration: | 12-Oct-2022 |
Description of the related object: | Supplementary Information |
Related object: | https://static-content.springer.com/esm/art%3A10.1007%2Fs11033-022-07884-2/MediaObjects/11033_2022_7884_MOESM1_ESM.docx |
Faculty: | M - Medizinische Fakultät |
Department: | M - Frauenheilkunde |
Professorship: | M - Prof. Dr. E.-F. Solomayer |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
File | Description | Size | Format | |
---|---|---|---|---|
s11033-022-07884-2.pdf | 912,15 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License