Please use this identifier to cite or link to this item: doi:10.22028/D291-37555
Title: A lack of a definite correlation between male sub-fertility and single nucleotide polymorphisms in sperm mitochondrial genes MT-CO3, MT-ATP6 and MT-ATP8
Author(s): Saleh Jaweesh, Mayyas
Hammadeh, Mohamad Eid
Dahadhah, Fatina W.
Al Smadi, Mohammad A.
Al Zoubi, Mazhar Salim
Alarjah, Manal Issam Abu
Amor, Houda
Language: English
Title: Molecular Biology Reports
Publisher/Platform: Springer Nature
Year of Publication: 2022
Free key words: Male sub-fertility
ATP6 and ATP8
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background An inability of a man to conceive a potentially fertile woman after a year of unprotected intercourse is defned as male infertility. It is reported that 30–40% of males in their reproductive years have abnormalities in sperm production, either qualitatively or quantitatively, or both. However, genetic factors result in up to 15% of male infertility cases. The present study aimed to analyze the possible correlations between sub-fertility and polymorphisms in sperm mitochondrial CO3, ATP6 and ATP8 genes in sub-fertile men. Methods and results For 67 sub-fertile and 44 fertile male samples, Sanger sequencing of selected mitochondrial DNA genes was done. A total of twelve SNPs in the MT-CO3 gene: rs2248727, rs7520428, rs3134801, rs9743, rs28358272, rs2853824, rs2856985, rs2854139, rs41347846, rs28380140, rs3902407, and 28,411,821, fourteen SNPs in the MT-ATP6: rs2001031, rs2000975, rs2298011, rs7520428, rs9645429, rs112660509, rs6650105, rs6594033, rs6594034, rs6594035, rs3020563, rs28358887, rs2096044, and rs9283154, and ten SNPs in the MT-ATP8: rs9285835, rs9285836, rs9283154, rs8179289, rs121434446, rs1116906, rs2153588, rs1116905, rs1116907, and rs3020563 were detected in the case and control groups at diferent nucleotide positions. Only the rs7520428 in the MT-CO3 and MT-ATP6 showed a statistically signifcant diference between sub-fertile and fertile groups in the genotype’s and allele’s frequency test (P<0.0001 for both). Conclusion The results of our study suggest that male sub-fertility is linked with rs7520428 SNP in MT-CO3 and MT-ATP6. The studied polymorphic variations in the MT-ATP8 gene, on the contrary, did not reveal any signifcant association with male sub-fertility.
DOI of the first publication: 10.1007/s11033-022-07884-2
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-375553
ISSN: 1573-4978
Date of registration: 12-Oct-2022
Description of the related object: Supplementary Information
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Frauenheilkunde
Professorship: M - Prof. Dr. E.-F. Solomayer
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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