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doi:10.22028/D291-36997 | Title: | Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease |
| Author(s): | Reinhardt, Sven Schuck, Florian Stoye, Nicolai Hartmann, Tobias Grimm, Marcus O. W. Pflugfelder, Gert Endres, Kristina |
| Language: | English |
| Title: | Cellular and molecular life sciences : CMLS |
| Volume: | 76 |
| Issue: | 5 |
| Startpage: | 1005 |
| Endpage: | 1025 |
| Publisher/Platform: | Springer |
| Year of Publication: | 2019 |
| Free key words: | ADAM10 Alpha-secretase APP-processing Kuzbanian Omb TBX2 Transcriptional regulation |
| DDC notations: | 610 Medicine and health |
| Publikation type: | Journal Article |
| Abstract: | The ADAM10-mediated cleavage of transmembrane proteins regulates cellular processes such as proliferation or migration. Substrate cleavage by ADAM10 has also been implicated in pathological situations such as cancer or Morbus Alzheimer. Therefore, identifying endogenous molecules, which modulate the amount and consequently the activity of ADAM10, might contribute to a deeper understanding of the enzyme's role in both, physiology and pathology. |
| DOI of the first publication: | 10.1007/s00018-018-2998-2 |
| URL of the first publication: | https://link.springer.com/article/10.1007/s00018-018-2998-2 |
| Link to this record: | urn:nbn:de:bsz:291--ds-369974 hdl:20.500.11880/33577 http://dx.doi.org/10.22028/D291-36997 |
| ISSN: | 1420-9071 1420-682X |
| Date of registration: | 5-Aug-2022 |
| Faculty: | M - Medizinische Fakultät |
| Department: | M - Neurologie und Psychiatrie |
| Professorship: | M - Prof. Dr. Tobias Hartmann |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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