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doi:10.22028/D291-36766
Title: | Prognostic Value of Oxygenated Hemoglobin Assessed during Acute Exacerbations of Chronic Pulmonary Disease |
Author(s): | Hinke, Clemens F. Jörres, Rudolf A. Alter, Peter Bals, Robert Bornitz, Florian Kreuter, Michael Herth, Felix J. F. Kahnert, Kathrin Kellerer, Christina Watz, Henrik Budweiser, Stephan Trudzinski, Franziska C. |
Language: | English |
Title: | Respiration |
Volume: | 100 |
Issue: | 5 |
Pages: | 387–394 |
Publisher/Platform: | Karger |
Year of Publication: | 2021 |
Free key words: | Acute exacerbations of chronic obstructive pulmonary disease Oxygenated hemoglobin Chronic obstructive pulmonary disease |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Background: Oxygenated hemoglobin(OxyHem) is a simple-to-measure marker of oxygen content capable of predicting all-cause mortality in stable chronic obstructive pulmonary disease (COPD). Objectives: We aimed to analyze its predictive value during acute exacerbations of COPD (AECOPD). Methods: In this retrospective study, data from 227 patients discharged after severe AECOPD at RoMed Clinical Center Rosenheim, Germany, between January 2012 and March 2018, was analyzed. OxyHem (hemoglobin concentration [Hb] × fractional SpO2, g/dL) was calculated from oxygen saturation measured by pulse oximetry and hemoglobin assessed within 24 h after admission. The follow-up (1.7 ± 1.5 years) covered all-cause mortality, including readmissions for severe AECOPD. Results: During the follow-up period, 127 patients died, 56 due to AECOPD and 71 due to other reasons. Survivors and non-survivors showed differences in age, FVC % predicted, C-reactive protein, hemoglobin, Cr, Charlson Comorbidity Index (CCI), and OxyHem (p < 0.05 each). Significant independent predictors of survival were BMI, Cr or CCI, FEV1 % predicted or FVC % predicted, Hb, or OxyHem. The predictive value of OxyHem (p = 0.006) was superior to that of Hb or SpO2 and independent of oxygen supply during blood gas analysis. OxyHem was also predictive when using a cutoff value of 12.1 g/dL identified via receiver operating characteristic curves in analyses including either the CCI (hazard ratio 1.85; 95% CI 1.20, 2.84; p = 0.005) or Cr (2.04; 95% CI 1.35, 3.10; p = 0.001) as covariates. Conclusion: The concentration of OxyHem provides independent, easy-to-assess information on long-term mortality risk in COPD, even if measured during acute exacerbations. It therefore seems worth to be considered for broader clinical use. |
DOI of the first publication: | 10.1159/000513440 |
URL of the first publication: | https://www.karger.com/Article/FullText/513440 |
Link to this record: | urn:nbn:de:bsz:291--ds-367660 hdl:20.500.11880/33407 http://dx.doi.org/10.22028/D291-36766 |
ISSN: | 1423-0356 0025-7931 |
Date of registration: | 12-Jul-2022 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Innere Medizin |
Professorship: | M - Prof. Dr. Robert Bals |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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