Please use this identifier to cite or link to this item: doi:10.22028/D291-36766
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Title: Prognostic Value of Oxygenated Hemoglobin Assessed during Acute Exacerbations of Chronic Pulmonary Disease
Author(s): Hinke, Clemens F.
Jörres, Rudolf A.
Alter, Peter
Bals, Robert
Bornitz, Florian
Kreuter, Michael
Herth, Felix J. F.
Kahnert, Kathrin
Kellerer, Christina
Watz, Henrik
Budweiser, Stephan
Trudzinski, Franziska C.
Language: English
Title: Respiration
Volume: 100
Issue: 5
Pages: 387–394
Publisher/Platform: Karger
Year of Publication: 2021
Free key words: Acute exacerbations of chronic obstructive pulmonary disease
Oxygenated hemoglobin
Chronic obstructive pulmonary disease
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background: Oxygenated hemoglobin(OxyHem) is a simple-to-measure marker of oxygen content capable of predicting all-cause mortality in stable chronic obstructive pulmonary disease (COPD). Objectives: We aimed to analyze its predictive value during acute exacerbations of COPD (AECOPD). Methods: In this retrospective study, data from 227 patients discharged after severe AECOPD at RoMed Clinical Center Rosenheim, Germany, between January 2012 and March 2018, was analyzed. OxyHem (hemoglobin concentration [Hb] × fractional SpO2, g/dL) was calculated from oxygen saturation measured by pulse oximetry and hemoglobin assessed within 24 h after admission. The follow-up (1.7 ± 1.5 years) covered all-cause mortality, including readmissions for severe AECOPD. Results: During the follow-up period, 127 patients died, 56 due to AECOPD and 71 due to other reasons. Survivors and non-survivors showed differences in age, FVC % predicted, C-reactive protein, hemoglobin, Cr, Charlson Comorbidity Index (CCI), and OxyHem (p < 0.05 each). Significant independent predictors of survival were BMI, Cr or CCI, FEV1 % predicted or FVC % predicted, Hb, or OxyHem. The predictive value of OxyHem (p = 0.006) was superior to that of Hb or SpO2 and independent of oxygen supply during blood gas analysis. OxyHem was also predictive when using a cutoff value of 12.1 g/dL identified via receiver operating characteristic curves in analyses including either the CCI (hazard ratio 1.85; 95% CI 1.20, 2.84; p = 0.005) or Cr (2.04; 95% CI 1.35, 3.10; p = 0.001) as covariates. Conclusion: The concentration of OxyHem provides independent, easy-to-assess information on long-term mortality risk in COPD, even if measured during acute exacerbations. It therefore seems worth to be considered for broader clinical use.
DOI of the first publication: 10.1159/000513440
URL of the first publication:
Link to this record: urn:nbn:de:bsz:291--ds-367660
ISSN: 1423-0356
Date of registration: 12-Jul-2022
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Robert Bals
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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