Please use this identifier to cite or link to this item:
Volltext verfügbar? / Dokumentlieferung
doi:10.22028/D291-36763
Title: | Blockade of PD-1 decreases neutrophilic inflammation and lung damage in experimental COPD |
Author(s): | Ritzmann, Felix Borchardt, Kai Vella, Giovanna Chitirala, Praneeth Angenendt, Adrian Herr, Christian Menger, Michael D. Hoth, Markus Lis, Annette Bohle, Rainer M. Bals, Robert Beisswenger, Christoph |
Language: | English |
Title: | American Journal of Physiology : Lung Cellular and Molecular Physiology |
Volume: | 320 |
Issue: | 5 |
Pages: | L958–L968 |
Publisher/Platform: | American Physiological Society |
Year of Publication: | 2021 |
Free key words: | COPD inflammation lung damage macrophages PD-1 PD-L1 |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Chronic obstructive lung disease (COPD) and lung cancer are both caused by smoking and often occur as comorbidity. The programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) axis is an important canonic immunoregulatory pathway, and antibodies that specifically block PD-1 or PD-L1 have demonstrated efficacy as therapeutic agents for non-small cell lung cancer. The role of the PD-1/PD-L1 axis in the pathogenesis of COPD is unknown. Here, we analyzed the function of the PD-1/PD-L1 axis in preclinical COPD models and evaluated the concentrations of PD-1 and PD-L1 in human serum and bronchoalveolar lavage (BAL) fluids as biomarkers for COPD. Anti-PD-1 treatment decreased lung damage and neutrophilic inflammation in mice chronically exposed to cigarette smoke (CS) or nontypeable Haemophilus influenzae (NTHi). Ex vivo stimulated macrophages obtained from anti-PD-1-treated mice released reduced amounts of inflammatory cytokines. PD-L1 concentrations correlated positively with PD-1 concentrations in human serum and BAL fluids. Lung sections obtained from patients with COPD stained positive for PD-L1. Our data indicate that the PD-1/PD-L1 axis is involved in developing inflammation and tissue destruction in COPD. Inflammation-induced activation of the PD-1 pathway may contribute to disease progression. |
DOI of the first publication: | 10.1152/ajplung.00121.2020 |
URL of the first publication: | https://journals.physiology.org/doi/full/10.1152/ajplung.00121.2020 |
Link to this record: | urn:nbn:de:bsz:291--ds-367634 hdl:20.500.11880/33404 http://dx.doi.org/10.22028/D291-36763 |
ISSN: | 1522-1504 1040-0605 |
Date of registration: | 11-Jul-2022 |
Description of the related object: | Supplemental material |
Related object: | https://figshare.com/ndownloader/files/26617658 |
Faculty: | M - Medizinische Fakultät |
Department: | M - Biophysik M - Chirurgie M - Innere Medizin M - Pathologie |
Professorship: | M - Prof. Dr. Robert Bals M - Prof. Dr. Rainer M. Bohle M - Prof. Dr. Markus Hoth M - Prof. Dr. Michael D. Menger |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
There are no files associated with this item.
Items in SciDok are protected by copyright, with all rights reserved, unless otherwise indicated.