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doi:10.22028/D291-36708
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Title: | TNF-related apoptosis-inducing ligand, interferon gamma-induced protein 10, and C-reactive protein in predicting the progression of SARS-CoV-2 infection : a prospective cohort study |
Author(s): | Tegethoff, Sina A. Danziger, Guy Kühn, Dennis Kimmer, Charlotte Adams, Thomas Heintz, Lena Metz, Carlos Reifenrath, Katharina Angresius, Rebecca Mang, Sebastian Rixecker, Torben Becker, André ![]() Geisel, Jürgen ![]() Jentgen, Christophe Seiler, Frederik Reichert, Matthias C. Fröhlich, Franziska Meyer, Sascha Rissland, Jürgen Ewen, Sebastian Wagenpfeil, Gudrun Last, Katharina Smola, Sigrun Bals, Robert ![]() Lammert, Frank ![]() Becker, Sören L. ![]() Krawczyk, Marcin Lepper, Philipp M. ![]() Papan, Cihan ![]() |
Language: | English |
In: | |
Title: | International Journal of Infectious Diseases |
Volume: | 122 |
Pages: | 178-187 |
Publisher/Platform: | Elsevier |
Year of Publication: | 2022 |
Free key words: | COVID-19 Severity prediction Host response Biomarkers TRAIL IP-10 CRP Point-of-care testing |
DDC notations: | 610 Medicine and health |
Publikation type: | Journal Article |
Abstract: | Background: Early prognostication of COVID-19 severity will potentially improve patient care. Biomarkers, such as TNF-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein 10 (IP-10), and C-reactive protein (CRP), might represent possible tools for point-of-care testing and severity prediction. Methods: In this prospective cohort study, we analyzed serum levels of TRAIL, IP-10, and CRP in patients with COVID-19, compared them with control subjects, and investigated the association with disease sever ity. Results: A total of 899 measurements were performed in 132 patients (mean age 64 years, 40.2% females). Among patients with COVID-19, TRAIL levels were lower (49.5 vs 87 pg/ml, P = 0.0142), whereas IP-10 and CRP showed higher levels (667.5 vs 127 pg/ml, P <0.001; 75.3 vs 1.6 mg/l, P <0.001) than healthy controls. TRAIL yielded an inverse correlation with length of hospital and intensive care unit (ICU) stay, Simplified Acute Physiology Score II, and National Early Warning Score, and IP-10 showed a positive cor relation with disease severity. Multivariable regression revealed that obesity (adjusted odds ratio [aOR] 5.434, 95% confidence interval [CI] 1.005-29.38), CRP (aOR 1.014, 95% CI 1.002-1.027), and peak IP-10 (aOR 1.001, 95% CI 1.00-1.002) were independent predictors of in-ICU mortality. |
DOI of the first publication: | 10.1016/j.ijid.2022.05.051 |
URL of the first publication: | https://www.sciencedirect.com/science/article/pii/S1201971222003150 |
Link to this record: | urn:nbn:de:bsz:291--ds-367080 hdl:20.500.11880/33352 http://dx.doi.org/10.22028/D291-36708 |
ISSN: | 1201-9712 |
Date of registration: | 8-Jul-2022 |
Description of the related object: | Supplementary materials |
Related object: | https://ars.els-cdn.com/content/image/1-s2.0-S1201971222003150-mmc1.docx |
Faculty: | M - Medizinische Fakultät |
Department: | M - Infektionsmedizin M - Innere Medizin |
Professorship: | M - Prof. Dr. Robert Bals M - Prof. Dr. Sören Becker M - Prof. Dr. Frank Lammert M - Keiner Professur zugeordnet |
Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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